ELECTED DRAINAGE COMMISSIONERS 2010/2011 Spoon River Drainage District, Docket No. 5, 97-MC-3 Mitchell J. Osterbur 2013 Russell Buhr CR 2300 E 2594 CR 2300 E St. Joseph, IL 61873 Gifford, IL 61847 217-369-3290 217-694-4551 Lotus Special Drainage District, Docket No. 8, 97-MC-6 Dean Liestman - 2013 Mike Wachstetter - CR 100 E 79 CR 3350 N Mahomet, IL 61853 Foosland, IL 61845 217-897-1368 217-846-3221 Newcomb Special Drainage District, Docket No. 12, 97-MC-10 Marvin Bell - 2013 Kevan Parrett - Timber Ridge Drive 180 CR 2400 N Mahomet, IL 61853 Mahomet, IL 61853 217-590-4265 217-586-3197 Stanton Special Drainage District, Docket No. 15, 97-MC-12 Steven Maddock 2013 Roger Flynn - CR 2200 E 2142 CR 1950 N St. Joseph, IL 61873 St. Joseph, IL 61873 217-469-2495 217-469-7442 Saline Branch Drainage District, Docket No. 19, 97-MC-15 Mack Weckel - 2013 Warren L. Rittenhouse - East Oaks Road 2918 Rutherford Dr. Urbana, IL 61802 Urbana, IL 61802 217-367-9790 217-344-1707 Little Vermilion Special Drainage District, Docket No. 21, 97-MC-17 Keith L. Kilian - 2013 Myron Luth - CR 2500 E 526 CR 2400 E Homer, IL 61849 Broadlands, IL 61816 217-834-3283 217-834-3176 Embarras River Special Drainage District, Docket No. 23, 97-MC-19 John Lannon - 2013 Scott Wilson - CR 500 N 510 S. Harrison Sidney, IL 61877 Philo, IL 61864 217-688-2048 217-684-2509 Dillsburg Special Drainage District, Docket No. 35, 97-MC-20 Dale Franzen- 2013 Rodney Bergman - CR 2000 E 3122 CR 2100 E Rantoul, IL 61866 Rantoul, IL 61866 217-568-7512 217-568-7269 Long Point Slough Special Drainage District, Docket No. 39, 97-MC-22 Randall R. Frick - 2013 Phillip Madigan - CR 200 N 70 CR 1750 E Longview, IL 61852 Villa Grove, IL 61956 217-684-2083 217-832-9757
Les Olson CR 1950 N St. Joseph, IL 61873 217-469-7139
Gary Fugh - N 4200 E Road Fisher, IL 61843 217-897-1213
Doug Turner - CR 2500 N Mahomet, IL 61853 217-586-4816/217-202-4816
Donald D. Routh - CR 1700 N St. Joseph, IL 61873 217-841-0757
Donald Flessner - Brownfield Road Urbana, IL 61802 217-328-1679
Tony Beck - E 550 N Road Allerton, IL 61810 217-288-9125
Todd Herbert - CR 1700 E Philo, IL 61864 217-684-2552
Kevin Rasor - CR 3100 N Rantoul, IL 61866 217-892-4925
Paul Luedke - CR 100 N Broadlands, IL 61816 217-834-3196
Elected Drainage District Commissioners Page 2
Hillsbury Slough Special Drainage District, Docket No. 40, 97-MC-23 Kenneth J. Hieser - 2013 L. Gene Heap - CR 3450 N 1036 E 300 N Foosland, IL 61845 Paxton, IL 60957 217-897-1116 217-749-2869 Big Slough Special Drainage District, Docket 41, 97-MC-24 Stephen A. Gordon - 2013 Gregory D. Suits - 2012 3051B CR 1300 E 925 North Dr. Rantoul, IL 61866 Rantoul, IL 61866 217-893-1087 217-202-1284 Kaskaskia Special Drainage District, Docket No. 49, 97-MC-26 James Kamradt - 2013 David Berbaum - CR 800 N 533 CR 1200 N Tolono, IL 61880 Champaign, IL 61822 217-369-6023 217-863-2681 Upper Salt Fork Drainage District, Docket No. 53, 97-MC-30 Darrin Flessner - 2013 Darius D. Harms CR 2300 N 2191 CR 2200 E St. Joseph, IL 61873 St. Joseph, IL 61873 217-694-4168 217-694-4132 Wildcat Special Drainage District, Docket No. 63, 97-MC-35 L. Gene Heap -2013 Lowell D. Pete Johnson - E 300 N 3215 CR 1700 E Paxton, IL 60957 Rantoul, IL 61866 217-749-2869 217-377-2902 Conkey Branch Special Drainage District, Docket No. 64, 97-MC-36 John W. Sadler - 2013 William A. Wilson - E. US Rte CR 1600 N Fithian, IL 61844 St. Joseph, IL 61873 217-582-2338 217-582-2670 East Lake Fork Special Drainage District, Docket No. 67, 97-MC-37 Gary L. Hixson - 2013 Ronald Starwalt - Harrington Drive 384 CR 600 N Champaign, IL 61821 Sadorus, IL 61872 217-356-5182 217-598-2592 Embarras River Mutual Drainage District, Docket No. 79, 97-MC-39 Gary Fisher - 2013 Scott Reifsteck - East Walnut 1341 CR 600 N Tolono, IL 61880 Tolono, IL 61880 217-485-8120 217-485-4915 Ludlow Special Drainage District, Docket No. 98, 97-MC-44 Patrick Quinlan - 2013 Clark Seibring - CR 2000 E 1780 N O Road Ludlow, IL 60949 Ludlow, IL 60949 217-396-7327 217-396-5721
Warren Birkey - N 1200 E Paxton, IL 60957 217-379-4107
Lowell Pete Johnson - CR 1700 E Rantoul, IL 61866 217-377-2902
Kenneth Gady - CR 500 E Sadorus, IL 61872 217-598-2228
Mark Weckel - East Oaks Road Urbana, IL 61802 217-337-6998
Paul Shields - CR 1300 E Rantoul, IL 61866 217-893-4285/217-377-4285
Robert McMahon - CR 2650 E Ogden, IL 61859 217-582-2755 or 369-2755

William J. Klein - CR 300 E Seymour, IL 61875 217-687-2656
Ted Meharry - River Road Tolono, IL 61880 217-485-2433
Richard D. Amsden - West Patton Paxton, IL 60957 217-379-8287 217-377-6394
Elected Drainage District Commissioners Page 3
Union D. D. No. 2 of the Towns of Somer and Stanton, Docket No. 104, 97-MC-46 Scott Kesler - 2013 Robert Clem - 2012 Dennis Huls - CR 1800 N 1982 CR 2100 N 1846 CR 2100 N Ogden, IL 61859 Urbana, IL 61802 Urbana, IL 61802 217-582-2887 217-694-4528 217-694-4561 Drainage District No. 1 of the Town of South Homer, Docket No. 105, 97-MC-47 Larry R. Frick 2013 Donald Tate - 2012 Robert Umbarger - South Main St. 709 S. Main St. 2 Catlin Homer Road Homer, IL 61849 Homer, IL 61849 Homer, IL 61849 217-896-2115 217-896-2688 217-896-2177 Union Drainage District No. 2 of the Towns of South Homer and Sidney, Docket No. 108, 97-MC-49 Paul Compton - 2013 Donald Morgan - 2012 Mark Baird - CR 2500 E 210 N. Ellen 844 CR 2500 E Homer, IL 61849 Homer, IL 61849 Homer, IL 61849 217-896-3046 217-896-2197 217-896-2008 Phinney Branch Mutual Drainage District, Docket No. 109, 97-MC-50 James E. Simon - 2013 William C. Ackermann - Branch Drive 1814 Maynard Lake Drive Champaign, IL 61821 Champaign, IL 61822 217-352-7241 217-359-0445 Camp Creek Special Drainage District, Docket No. 110, 97-MC-51 J. Chris Karr - 2013 William C. Jay - CR 300 E 225 CR 1900 N Seymour, IL 61875 Seymour, IL 61875 217-687-2602 217-202-2234
John M. Peisker - Roxford Drive Champaign, IL 61822 217-356-2852
Greg Miller - CR 1900 N Seymour, IL 61875 217-586-4721
Union D. D. by User #1 of the Township of Raymond and Murdock Township, Docket No. 111, 97-MC-52 Charles P. Eisenmenger 2013 Patrick Madigan - 2012 Delbert E. Warnes - CR 2000 E 14 CR 2100 E 108 South Johnson Longview, IL 61852 Longview, IL 61852 Longview, IL 61852 217-369-0281 217-834-3200 217-834-3108 Drainage District No. 1 of the Town of Stanton, Docket No. 112, 97-MC-53 David W. Waters 2013 Dwayne Gilliland - CR 1800 E 2072 CR 1900 E Urbana, IL 61802 Urbana, IL 61802 217-202-3958/217-694-4162 217-694-4108 Drainage District No. 1 of the Town of Condit, Docket No. 113, 97-MC-54 Kenneth E. Coffin - 2013 John G. Murray - CR 2800 N 2607 CR 1000 E Rantoul, IL 61866 Champaign, IL 61822 217-892-8180 217-643-7440 Dry Fork Mutual Drainge District, Docket No. 114, 97-MC-55 Sheila M. Loftus - 2013 Vicki L. Goodmann - CR 100 E 91 CR 400 E Ivesdale, IL 61851-9714 Sadorus, IL 61872 217-564-2312 217-867-2025/621-9821

Gayle Bartell - CR 1900 E Urbana, IL 61802 217-694-4504
Christine Wallace - CR 1000 E Champaign, IL 61822 217-897-1252
Elaine M. Aaltonen - Boulevard View Waukegan, IL 60087 847-249-1943
Elected Drainage District Commissioners Page 4 Union D. D. No. 1 of the Towns of Ogden and Oakwood, Docket 118, 97-MC-59 Mark Shepherd - 2013 Eugene Miller - 2012 Gary Olson - E 1950 N 309 E 1900 N 1810 CR 2275 E Fithian, IL 61844 Ogden, IL 61859 St. Joseph, IL 61873 217-548-2287 217-582-2715 217-469-2174 Drainage District No. 1 of the Town of Crittenden, Docket No. 120, 97-MC-61 Brad T. Johns - 2013 Jerry Watson - 2012 Jeff Watson - E CR 100 N 56 CR 1650 E 198 CR 1700 E Villa Grove, IL 61956 Villa Grove, IL 61956 Villa Grove, IL 61956 217-202-6561 217-832-8223/217-202-9800 217-684-2039 Drainage District No. 1 of the Town of Sidney, Docket No. 122, 97-MC-63 Vacant - 2013 Kent Krukewitt - CR 2400 E Homer, IL 61849 217-896-2195
Eugene O'Neill - Lincoln Trail Rd. Fithian, IL 61844 217-260-6370
Union D. D. No. 7 of the Towns of St. Joseph and Ogden, Docket 128, 97-MC-68 David E. Marsh- 2013 Bradley Marsh - 2012 Vacant - CR 2200 E 1703 CR 2350 E St. Joseph, IL 61873 St. Joseph, IL 61873 217-469-2147 217-469-2665 Flatville Special Drainage District, Docket No. 57-1/2, 97-MC-70 Marc Duitsman - 2013 Gary Busboom (App.) - CR 2600 N 2073 CR 2600 N Gifford, IL 61847 Gifford, IL 61847 217-840-4795 217-493-4738 Drainage District No. 2 in the Town of Sidney, Docket No. 60, 97-MC-73 Roger L. Negangard - 2013 Charles Negangard - CR 2000 E 1883 CR 700 N Sidney, IL 61877 Sidney, IL 61877 217-688-2992 217-684-2004
Derald Ackerman - South Main Gifford, IL 61847 217-202-5452
Robert B. Rice - South Adams Street Philo, IL 61864 217-684-2147

Gary J. Fisher Professor University of Michigan Department of Dermatology Comprehenisve Cancer Center Member EDUCATION University of California San Diego (Biology) 1974 Cornell University, Ph.D. (Biochemistry) 1980 POSTDOCTORAL TRAINING Washington University, Biological Chemistry, 1980-1983 Washington University, Laboratory Medicine, 1983-1985 HONORS AND AWARDS University of California Presidents Research Award, 1974 University of Michigan Inventor Recognition Award, 2001 University of Michigan Medical School Deans Award for Achievement in Clinical and Basic Science Research, 2001 MEMBERSHIPS AND OFFICES IN PROFESSIONAL SOCIETIES 1998-present Society for Photobiology 1993-present American Association for the Advancement of Science 1986-present American Society for Biochemistry and Molecular Biology 1986-present Society for Investigative Dermatology 1990-1992 Skin Pharmacology 2004-present American Society for Matrix Biology GRANT SUPPORT National Institute of Health Principal Investigator TGF- Signaling in Photoaged and Chronologically Aged Human Skin 02/01/02 01/31/07 National Institute of Health Principal Investigator Recept. Protein Tyrosine Phosphatase Regulation of EGFR 07/01/05 to 05/31/2010 Natinal Institute of Health Principal Investigator Collagenase Degradation of Extracellular Matrix in Aging 09/01/06 to 06/30/11 National Institute of Health (Kang) Co-Investigator UV-induced Collagen Reduction for Treating Skin Scleroderma 07/01/01 to 06/31/2007

Gary J. Fisher, Ph.D. 7

EXTRAMURAL INVITED PRESENTATIONS International Topical retinoic acid increases transforming growth factor-beta 1 immunoreactivity but not its mRNA in human epidermis in vivo, International Investigative Dermatology, Washington DC, 1990. Quantitation of endogenous nuclear retinoid receptor proteins in human epidermis in vivo: High levels of retinoic acid receptor gamma and retinoid X receptor alpha that bind to a retinoic acid response element exclusively as heterodimers, International Investigative Dermatology, Japan, 1994. UVB Activates Stress-Activated Protein Kinases, fos/jun and fos/jun Driven Dermis-Degrading Proteinases in Human Skin in vivo, European Society for Dermatological Research, Amsterdam, 1996. The transcription factor c-jun is critical for ultraviolet irradiation-induced premature aging and its prevention by retinoic acid in human skin in vivo; European Society for Dermatological Research, Italy, 1997. Ultraviolet irradiation rapidly activates cell surface receptors and three distinct MAP kinase modules in human skin in vivo, Society for Investigative Dermatology, Cologne Germany, 1998. UV Signal Transduction in Human Skin, Korean Dermatological Association, Seoul Korea, April 26, 2000. UV Signaling in Human Skin, Seoul University, April 28, 2000. UV-Induced Cell Signalling Pathway, International Workshop on Molecular Mechanisms of Tanning, Nice France, April 26-29, 2001. Regulation of UV-induced Signal Transduction by Receptor Protein Tyrosine Phosphatases in Human Skin, Southampton England, GlaxoSmithKline Guest Speaker, British Society for Investigative Dermatology, April 7-9, 2003. Ultraviolet Irradiation Activates NF- Pathway via Association of IB Kinase-/NEMO with IB kinase- and IB- in Human Keratinocytes. International Investigative Dermatology, April 30-May 4, 2003. Ultraviolet light irradiation indeuced signal transduction in skin photoaging, Japanese Society for Investigative Dermatology, Kyoto Japan, 2003. UV-induced Signaling Pathway that Mediate Photoaging in Human Skin, 14th International Congress on Photobiology, Jeju Korea, June 10-14, 2004. Connective Tissue Growth Factor: a Key Regulator of Collagen Production is Reduced in Aged Human Skin in vivo, 35th Annual European Society for Dermatological Research, Tuebingen Germany, September 21-25, 2005. UV Irradiation Activation of EGFR That Drives Photoaging Is Mediated by Oxdative Inhibition of Receptor Type Protein Tyrosine Phosphatase-Kappa In Human Skin, 36th Annual European Society for Dermatological Research, Paris France, September 6-11, 2006. EXTRAMURAL INVITED PRESENTATIONS (contd) National "Protein kinase C regulates terminal differentiation in cultured adult human keratinocytes", Society for Investigative Dermatology, Washington, D.C., 1988.

Gary J. Fisher, Ph.D. 8

"Protein kinase C isoforms alpha and beta are expressed in adult human epidermis", Society for Investigative Dermatology, Washington D.C., 1989. "Genes for the calcium independent protein kinase C isoforms delta, epsilon, & L are expressed in human epidermis and cultured keratinocytes", Society for Investigative Dermatology, Seattle, Washington, 1991. Differential expression of conventional and nonconventional protein kinase C isozymes in normal and psoriatic skin, Society for Investigative Dermatology, 1992. Protein kinase C isoenzymes alpha and epsilon are translocated and down-regulated by phorbol ester and bryostatin-1 in human keratinocytes and fibroblasts, Society for Investigative Dermatology, 1993. Ultraviolet irradiation rapidly upregulates transcription factors AP-1 and NF-B and subsequently induces expression of target genes for matrix-degrading metalloproteinases in human skin in vivo, Society for Investigative Dermatology, 1995. Retinoic acid antagonizes UVB activation of AP-1 and inhibits induction of matrix metalloproteinases in human epidermis and dermis in vivo, Society for Investigative Dermatology, 1996. Ultraviolet irradiation damages the dermis by both degrading collagen and inhibiting procollagen synthesis: Protection by all-trans retinoic acid in human skin in vivo, Society for Investigative Dermatology, 1997. Overview of Growth Factors and Signal Transduction, Society for Investigative Dermatology, Chicago IL, 1999. Mechanisms of Photoaging, Parke-Davis Warner Lambert, June 7, 2000 Retinoids in research and human skin, Galderma and Society for Investigative Dermatology, May 1419, 2002. UV regulation of collagen in human skin, Scleroderma Workshop, Boston University, May 20-22, 2002. UV regulation of TGF- signaling in human skin, University of Illinois at Chicago Rheumatology Grand Rounds, November 19-20, 2002. The Pathophysiology of Damaged Skin, Contemporary Perspectives on Topical Retinoids, Ameila Island FL, March 22, 2004. When does skin aging begin?, NIH Aging Workshop, Bethesda MD, May 5-7, 2004. Eliciting the wound healing response to rejuvenate aged skin, North American Center for Continuing Medical Education, San Diego CA, April 21-24, 2005.

Gary J. Fisher, Ph.D. 9

EXTRAMURAL INVITED PRESENTATIONS (contd) University of Michigan PKC isoenzymes expression and function in human skin, Graduate Seminar in Pharmacology, 1994. Matrix metalloproteinases as mediators of UV-induced skin damage, Graduate Seminar in Biochemistry, 1995. UV signaling pathways in human skin, Graduate Seminar in Physiology, 1998. Mechanisms of premature skin aging, Graduate Seminar in Organogenesis of the Skin, 1999. Retinoid signaling in human skin, Graduate Seminar in Organogenesis of the Skin, 1999. The mechanisms of Photoaging, U of Michigan Medical School Sesquicentennial, October 13, 2000. UV Signaling in human keratinocytes, St Louis University, March 20, 2001. UV signaling in human skin, Basic Science Seminar for Nephrology, U of Michigan, March 27, 2001. OTHER PRESENTATIONS International "Protein kinase C in normal and psoriatic adult human epidermis", Recent Advances in Prostaglandin and Leukotriene Research Florence, Italy, 1987 "Cyclosporine A inhibits growth of human keratinocytes in serum free, but not serum containing media", International Conference on Mechanisms of Cyclosporine Action, Washington D.C., 1988. "Properties and functions of protein kinase C in psoriasis", Sandoz Research Institute, Vienna, Austria, 1990. "Expression and function of protein kinase C in psoriasis", International Psoriasis Meeting, San Francisco, California, 1991. "Pharmacological, cellular and molecular aspects of topical retinoic acid treatment in humans", Retinoids 10 years On, Geneva, Switzerland, 1991. All-trans retinol mimics the biological effects of all-trans retinoic acid in human skin through metabolic conversion to all-trans retinoic acid, Retinoids 1995, Sophia Antipolis, France, 1995. Effect of All-trans-retinoic Acid on Aging Processes, FASEB Summer Conference, Snowmass, Colorado, 1996. Retinol Metabolism and actions in human skin, Retinoids 97, France, 1997. Molecular mechanisms of photoaging and its prevention by retinoic acid: ultraviolet irradiation induces MAP kinase signal transduction cascades that induce AP-1-regualted matrix metalloproteinases that degrade human skin in vivo, 46th Symposium on the Biology of Skin, Snowmass Colorado, 1997. Retinoic Acid Antagonism of AP-1 in UV-Irradiated Human Skin, FASEB Summer Conference, Snowmass, Colorado, 1997 Retinoids, FASEB Summer Research Conference, Snowmass Colorado, June 13-18, 1998. Molecular Pathophysiology of Photoaging in Human Skin and the Effect of all-trans Retinoic Acid, Biologic Effects of Light Symposium, Basel, Switzerland, November 1-3, 1998.

Gary J. Fisher, Ph.D. 10

OTHER PRESENTATIONS (contd) National "Role of protein kinase C in the pathophysiology of psoriasis", Sphinx Pharmaceuticals, Durham, North Carolina, 1990. "Phosphoinositide mediated signal transduction in normal and psoriatic epidermis", Psoriasis Workshop, Park City, Utah, 1990. "Role of the phospholipase c/protein kinase C signal transduction system in psoriasis", Schering-Plough, Bloomfield, New Jersey, 1991. "Role of protein kinase C in regulation of cellular homeostasis in human skin", Collagen Corporation, Palo Alto, California, 1992. "Role of the phospholipase c/protein kinase C signal transduction system in cutaneous inflammation", Hoffman LaRoche, Nutley, New Jersey, 1992. "Properties and functions of protein kinase C isoenzymes in normal and psoriatic human skin", Keystone Symposium, Silverthorne, CO, 1994. The retinoid signaling pathway in human skin, St. Louis University, St. Louis, Missouri, 1995. Ultraviolet irradiation induced signal transduction leading to matrix metalloproteinase gene expression in human skin in vivo, American Society for Photobiology, St Louis MO, 1997. All-trans retinoid acid protects against increased collagen breakdown and reduced collagen synthesis caused by ultraviolet irradiation in human skin in vivo, American Society for Photobiology, Snowbird, Utah July 13-16, 1998. Photoaging Caused by Ultraviolet Irradiation in Human Skin in vivo Results in Increased Collagen Breakdown and Reduced Collagen Synthesis, NIAMS Research Workshop on Risks and Benefits of Exposure to Ultraviolet Radiation and Tanning, Washington DC September 16-18, 1998. UV Signaling in Human Skin, University of Texas Southwestern, Dallas TX January 25, 1999 UV Signal Transduction and Human Skin Aging, State University of New York, Stony Brook, NY, March 18, 1999. BIBLIOGRAPHY Completed Publications in Scientific Journals Peer Reviewed Publications Paper listed below have been cited 5,160 times: ISI web of science (03/21/05). 1. Trzaskos JM, Bowen W, Fisher GJ, Billheimer JT, Gaylor JL: Microsomal enzymes of cholesterol biosynthesis from lanosterol. Lipids 17:250-256, 1981. 2. Fisher GJ, Fukushima H, Gaylor JL: Isolation, purification, and characterization of a unique form of cytochrome P-450 in microsomes of isosafrole-treated rats. J Biol Chem 256:4388-4394, 1981. 3. Fisher GJ, Gaylor JL: Kinetic investigation of rat liver microsomal electron transport from NADH to cytochrome P-450. J Biol Chem 257:7449-7455, 1981. 4. Trzaskos JM, Bowen WD, Fisher GJ, Billheimer JT, Gaylor JL: Microsomal enzymes of cholesterol biosynthesis from lanosterol: a progress report. Lipids 17:250-256, 1982. 5. Fisher GJ, Gaylor JL: Kinetics investigation of rat liver microsomal electron transport from NADH to cytochrome P-450. J Biol Chem 257:7449-7455, 1982.

Gary J. Fisher, Ph.D. 14

58. 59.

61. 62. 63.

65. 66. 67. 68.
Fisher GJ, Talwar HS, Tavakkol A, Esmann J, Baldassare JJ, Elder JT, Griffiths CEM, Baadsgaard O, Cooper KD, Voorhees JJ: Phosphoinositide mediated signal transduction in normal and psoriatic epidermis. J Invest Dermatol 95:15s-17s, 1990. Fisher GJ, Talwar HS, Baldassare JJ, Henderson PA, Voorhees JJ: Increased phospholipase C-catalyzed hydrolysis of phosphatidylinositol-4,5-bisphosphate and 1,2-sn-diacylglycerol content in psoriatic involved compared to uninvolved and normal epidermis. J Invest Dermatol 95:428-435, 1990. Cooper KD, Hammerberg C, Baadsgaard O, Elder JT, Chan LS, Taylor RS, Voorhees JJ, Fisher GJ: Interleukin-1 in human skin: dysregulation in psoriasis. J Invest Dermatol 95: 24S-26S, 1990. Fisher GJ, Hendersen PA, Voorhees JJ, Baldassare JJ: Epidermal growth factor-induced hydrolysis of phosphatidylcholine by phospholipase D and phospholipase C in human dermal fibroblasts. J Cell Physiol 146:309-317, 1991. Hammerberg C, Fisher GJ, Voorhees JJ, Cooper KD: Elevated thymidine phosphorylase activity in psoriatic lesions accounts for the apparent presence of an epidermal "growth inhibitor" but is not itself growth inhibitory. J Invest Dermatol 97:286-290, 1991. Elder JT, Fisher GJ, Zhang QY, Eisen D, Krust A, Kastner P, Chambon P, Voorhees JJ: Retinoic acid receptor gene expression in human skin. J Invest Dermatol 96:425-433, 1991. Reed JC, Talwar HS, Cuddy M, Baffy G, Williamson J, Rapp UR, Fisher GJ: Mitochondrial protein p26 BCL2 reduces growth factor requirements of NIH3T3 fibroblasts. Exp Cell Res 195(2):277-283, 1991. Fisher GJ, Esmann J, Griffiths CEM, Talwar HS, Hammerberg C, Elder JT, Karabin GD, Nickoloff BJ, Cooper KD, Voorhees JJ: Cellular, immunological and biochemical characterization of topical retinoic acid treated human skin. J Invest Dermatol 96(5):699-707, 1991. Duell EA, Fischer V, Fisher GJ, Astrom A, Voorhees JJ: Cyclosporine A metabolism by cytochrome P450 IIII occurs in microsomes from rat liver but not from normal epidermis or psoriatic lesions. J Invest Dermatol 96(6):827-31, 1991. Kim NI, Hammerberg C, Fisher GJ, Baadsgaard O, Voorhees JJ, Cooper KD: Psoriatic skin reveals the in vivo presence of an epidermal IL-1 inhibitor. Arch Dermatol Res 284:71-76, 1992. Fligiel SG, Inman DR, Talwar HS, Fisher GJ, Voorhees JJ, Varani J: Modulation of growth in normal and malignant melanocytic cells by all-trans retinoic acid. J Cutan Pathol 19(1):27-33, 1992. Klein SB, Fisher GJ, Mendelsohn J, Voorhees JJ, Elder JT: Regulation of TGF- expression in human keratinocytes: PKC-dependent and independent pathways. J Cell Physiol 151(2):326-336, 1992. Fisher GJ, Tavakkol A, Griffiths CEM, Elder JT, Zhang Q-Y, Finkel L, Danielpour D, Glick AB, Higley H, Ellingsworth L, Voorhees JJ: Differential modulation of transforming growth factor-1 expression and mucin deposition by retinoic acid and sodium lauryl sulfate in human skin. J Invest Dermatol 98:102-108, 1992. Baldassare JJ, Henderson PA, Burns D, Loomis C, Fisher GJ: Translocation of protein kinase C isozymes in thrombin-stimulated human platelets. J Biol Chem 267(22):15585-15590, 1992. Tavakkol A, Elder JT, Griffiths CEM, Cooper KD, Talwar H, Fisher GJ, Keane KM, Foltin SK, Voorhees JJ: Expression of growth hormone receptor, insulin-like growth factor I (IGF-I) and IGF-I receptor mRNA and proteins in human skin. J Invest Dermatol 99(3):343-349, 1992. Hammerberg C, Arend WP, Fisher GJ, Chan LS, Berger AE, Haskill JS, Voorhees JJ, Cooper KD: Interleukin-1 receptor antagonist in normal and psoriatic epidermis. J Clin Invest 90:571-583, 1992.

143. 144.

145. 146.

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150. 151.

155. 156.

Varani J, Schuger L, Dame MK, Leonard C, Fligiel SE, Kang S, Fisher GJ, Voorhees JJ: Reduced fibroblast interaction with intact collagen as a mechanism for depressed collagen synthesis in photodamaged skin. J Invest Dermatol 122:1471-1479, 2004. Orringer JS, Kang S, Johnson, Karimipour DJ, Hamilton T, Hammerberg C, Voorhees JJ, Fisher GJ: Tretinoin treatment prior to CO2 laser resurfacing: a clinical and biochemical analysis. 51:940-946, J Amer Acad Dermatol, 2004. Quan T, He T, Voorhees JJ, Fisher GJ: Ultraviolet irradiation induces Smad7 via induction of transcription factor AP-1 in skin fibroblasts. J Biol Chem 280:8079-8085, 2005. Bhagavathula N, Nerusu KC, Fisher GJ, Liu G, Thakur AB, Gemmell L, Kumar S, Xu H, Hinton P, Tsurushita N, Landolfi NF, Voorhees JJ, Varani J: Amphiregulin and epidermal hyperplasia: amphiregulin is required to maintain the psoriatic phenotype of human skin grafts on SCID mice. Amer J Pathol 166:1009-1016, 2005. Karimipour DJ, Kang S, Johnson TM, Orringer JS, Hamilton T, Hammerberg C, Voorhees JJ, Fisher GJ: Microdermabrasion: A molecular analysis following a single treatment. J Amer Acad Dermatol 52:25223, 2005. Bhagavathula N, Nerusu KC, Fisher GJ, Liu G, Landolfi N, Voorhees JJ, Varani J. Amphiregulin and epidermal hyperplasia: Amphiregulin is required to maintain the psoriatic phenotype of human skin grafts on SCID mice. Amer J Pathol 166(4):1009-1016, 2005. Kang S, Cho S, Chung JH, Fisher GJ, Voorhees JJ: Inflammation and extracellular matrix degradation mediated by activated transcription factors NFB and AP-1 in inflammatory acne lesions in vivo. Amer J Pathol, 166(6):1691-1699, 2005. Xu Y and Fisher G: Ultraviolet (UV) Light Irradiation Induced Signal Transduction in Skin Photoaging. Journal of Dermatological Science Supplement 1:S1-S8, 2005. Xu Y, Tan, L-J, Grachtchouk V, Voorhees J, and Fisher G: Receptor-type Protein-tyrosine Phosphatasek Regulates Epidermal Growth Factor Receptor Function. Journal of Biological Chemistry 280:4269442700, 2005. Quan TH, He TY, Shao Y, Kang S, Voorhees JJ, Fisher GJ: Elevated Cysteine-rich protein 61 (CYR61/CCN1), mediates aberrant collagen homeostasis in chronologically-aged and photoaged human skin, Amer J Pathol, 169(2):482-490, 2006.

Non-Peer-Reviewed Publications 1. Fisher GJ: Ph.D. Thesis, Cornell University, Ithaca, New York, 1982. Chapters In Books 1. Livingston RB, Calloway DH, MacGregor JS, Fisher GJ, Hastings AB: U.S. poverty impact on brain development. In, Growth and Development of the Brain (M.A.B. Brazier, Ed.) Raven Press, New York, 1988, pp 377-394. 2. Kragballe K, Fisher GJ, Voorhees JJ: Modulators of cutaneous inflammation and proliferation in psoriasis. In, Immune Mechanisms in Cutaneous Disease (DA Norris ed). Marcel Dekker, Inc., New York, 1989, pp 403-424. 3. Baadsgaard O, Cooper KD, Elder JT, Ellis CN, Esmann J, Fisher GJ, Klein SB, Nickoloff BJ, Talwar HS, Voorhees JJ: Pathomechanisms of psoriasis: New developments and summary. In, Sandimmun Cyclosporin in Psoriasis (K. Kragballe, B. Lumholtz, eds.), FADL, Copenhagen, 1989, pp 28-32.

Gary J. Fisher, Ph.D. 21

5. 6. 7.
Baadsgaard O, Cooper KD, Elder JT, Ellis CN, Esmann J, Fisher GJ, Klein SB, Nickoloff BJ, Talwar H, Voorhees JJ: Clinical experience with ciclosporin in psoriasis: Conclusions and perspectives. In, Sandimmun Ciclosporin in Psoriasis (K. Kragballe, B. Lumholtz, eds.), FADL, Copenhagen, 1989, pp 89-94. Kragballe K, Fisher GJ, Voorhees JJ: Eicosanoids in inflammatory and immunologic skin disorders. In, The Skin Immune System (JD Bos, ed), CRC Press, Boca Raton, 1990, pp 243-255. Kragballe K, Fisher GJ, Voorhees JJ: Eicosanoids, phosphoinositides, and the pathophysiology of psoriasis. In, Eicosanoids and the Skin, (T Ruzika, ed), CRC Press, Boca Raton, 1990, pp 68-78. Elder JT, Fisher GJ, Duell EA, Kragballe K, Voorhees JJ: Regulation of keratinocyte growth and differentiation: Interactive signal transduction pathways. In, Physiology, Biochemistry, and Molecular Biology of the Skin, (L Goldsmith, ed), Oxford University Press, New York, New York, pp. 266-313, 1991. Fisher GJ, Astrom A, Elder JT, Griffiths CEM, Higley H, Voorhees JJ: Topical retinoids pharmacological, cellular and molecular aspects. In, Retinoids: 10 Years On, (JH Saurat, ed), Karger, Basle, Switzerland, pp 152-166, 1991. Fisher GJ, Voorhees JJ: Molecular pathophysiology of photoaging in human skin and the effect of alltrans retinoic acid. In, Biologic effects of light, (Holick MF, Jung EG, eds), Kluwer Academic Publishers, Boston, MA, pp 175-180, 1999. Chung JH, Kang S, Fisher GJ: The molecular mechanisms of retinoid effects in human skin. In, Advances in Dermatology, William James and Kim Yancy, eds., Mosby Inc., St. Louis, MO, 1999. Kang S, Fisher GJ, Voorhees JJ: Pharmacology and molecular mechanisms of retinoid action in skin. In, Vitamin A and retinoids: An update of biological aspects and clinical applications, (Livrea MA, ed), Birkhauser Verlag, Basel, Switzerland, pp 151-159, 2000. Ritti L, Fisher GJ: Culture of adult human skin fibroblasts. In, Fibrosis Research: Methods and Protocols, (Varga J, Brenner DA, Phan SH, eds) Humana Press, Totwa, NJ, 2005.

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71. 72.

75. 76.

Kurlandsky SB, Voorhees JJ, Fisher GJ: Retinoic acid induces retinol esterification by lecithin retinol acyl transferase in proliferating cultured human keratinocytes. J Invest Dermatol 104(4):595, 1995. Reddy AP, Fisher GJ, Voorhees JJ: Retinoic acid induces orphan receptor COUP-TF I which functions to suppress retinoic acid-induced gene expression in cultured human keratinocytes. J Invest Dermatol 104(4)596, 1995. Fisher GJ, Duell EA, Datta SC, Voorhees JJ: Retinoic acid receptor-g in human skin strongly prefers all-trans retinoic acid as its ligand rather than 9-cis retinoic acid. J Invest Dermatol 104(4):596, 1995. Wang ZQ, Datta SC, Duraiswamy N, Kang S, Voorhees JJ, Fisher GJ: All-trans retinoic acid blocks UVB-induction of stromelysin I, but not its inhibitor tissue inhibitor of metalloproteinase-1 in human skin in vivo. J Invest Dermatol 106(4):898, 1996. Reddy AP, Fisher GJ, Voorhees JJ: Nuclear receptor COUP-TF antagonizes retinoic acid, vitamin D3 and thyroid hormone-induced gene transcription in human keratinocytes. J Invest Dermatol 106(4):818, 1996. Talwar HS, Wang ZQ, Fisher GJ, Voorhees JJ: Ultraviolet irradiation activates matrix metalloproteinases via AP-1 complexes composed of c-jun, jun-B, jun-D, c-fos, fra-1 and fra-2 through both post-transcriptional mechanisms in human skin in vivo. J Invest Dermatol 106(4):838, 1996. Kurlandsky SB, Duell EA, Voorhees JJ, Fisher GJ: Retinoic acid stimulates retinol esterification, thereby limiting retinoic acid synthesis in human keratinocytes. J Invest Dermatol 106(4):817, 1996. Asuru AI, Fisher GJ, Voorhees JJ: Quantitation and characterization of 1,25-dihydroxyvitamin D3, and thyroid hormone nuclear receptors in human epidermis in vivo. J Invest Dermatol 106(4):905, 1996. Marikar Y, Duell EA, Voorhees JJ, Fisher GJ: Regulation, properties, and solubilization of a unique cytochrome P-450 that specifically metabolizes all-trans retinoic acid to less active 4-hydroxy retinoic acid in human keratinocyte HACAT cells. J Invest Dermatol 106(4):807, 1996. Fisher GJ, Talwar HS, Duraiswamy N, Lin P, Kang S, Voorhees JJ: Retinoic acid antagonizes UVB activation of AP-1 and inhibits induction of matrix metalloproteinases in human epidermis and dermis in vivo. J Invest Dermatol 106(4):808, 1996. Lin P, Talwar HS, Wang ZQ, Voorhees JJ, Fisher GJ: Ultraviolet irradiation and platelet-derived growth factor activate distinct map kinase signal transduction pathways that regulate transcription factor AP-1 and collagenase gene expression in human skin fibroblasts. J Invest Dermatol 106(4):910, 1996. Reynolds NJ, McCombie SW, Shanker BB, Bishop WR, Fisher GJ: SCH 47112, a novel staurosporine derivative, inhibits 12-0-tetradecanoylphorbol-13-acetate-induced inflammation and epidermal hyperplasia in hairless mouse skin. J Invest Dermatol 106(4):911, 1996. Wang ZQ, Datta S, Duell EA, Kang S, Petkovich M, White JA, Voorhees JJ, Fisher GJ: Ultraviolet irradiation induces a state of functional retinoid deficiency through reduction of nuclear retinoid receptors in human skin in vivo. J Invest Dermatol 108(4): 545, 1997. Li XY, Xiao JH, Qin L, Fisher GJ, Voorhees JJ: Identification of transcription factors involved in ultraviolet irradiation induction of c-Jun gene expression in human skin in vivo. J Invest Dermatol 108(4):557, 1997. Fisher GJ, McPhillips F, Wang ZQ, Talwar HS, Li X-Y, Lin PP, Kang S, Voorhees JJ: Ultraviolet irradiation stimulates stress-activated MAP kinases c-Jun and c-Jun/c-Fos AP-1 complexes capable of driving matrix-degrading proteinases in human skin in vivo. J Invest Dermatol 108(4):557, 1997.

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Varani J, Kang S, Datta SC, Fisher GJ, Voorhees JJ: Topical treatment of 80+ year old individuals with retinol induces keratinocyte and fibroblast proliferation and reduces matrix metalloproteinase (MMP) expression. J Invest Dermatol 108(4):567, 1997. Fisher GJ, Talwar HS, Wang ZQ, McPhillips F, Madore S, Voorhees JJ: Retinoic acid antagonizes activation of transcription factor AP-1 by ultraviolet irradiation through a novel mechanism in human skin in vivo: Inhibition of c-Jun Protein expression. J Invest Dermatol 108(4):578, 1997. McPhillips F, Lin P, Wang ZQ, Voorhees JJ, Fisher GJ: Ultraviolet irradiation induces stressactivated protein kinases, transcription factors c-Jun and ATF-2, and c-Jun/ATF-2 regulated c-Jun gene expression trough an antioxidant sensitive mechanism that is mimicked by hydrogen peroxide in human keratinocytes. J Invest Dermatol 108(4):620, 1997. Fisher GJ, Datta SC, Talwar HS, Kang S, Voorhees JJ: Ultraviolet irradiation damages the dermis by both degrading collagen and inhibiting procollagen synthesis: Protection by all-trans retinoic acid in human skin in vivo. J Invest Dermatol 108(4):624, 1997. Wang ZQ, Talwar HS, Kang S, Fisher GJ, Voorhees JJ: Glucocorticoid and retinoic acid inhibit ultraviolet irradiation induction of cytokine and matrix-degrading metalloproteinase genes through distinct mechanisms in human skin in vivo. J Invest Dermatol, 110(4):490, 1998. Wan YS, Voorhees JJ, Fisher GJ: Ultraviolet irradiation generates reactive oxygen through activation of cell surface receptor-coupled NADPH oxidase in human keratinocytes and human skin in vivo. J Invest Dermatol, 110(4):489, 1998. Fisher GJ, Datta SC, Wang ZQ, Voorhees JJ: Retinoic acid protects against loss of types I and III procollagen caused by a single exposure to ultraviolet irradiation in human skin in vivo. J Invest Dermatol, 110(4):597, 1998. Varani J, Warner R, Kang S, Fisher GJ, Voorhees JJ: Collagen I and collagen III expression in young and old skin: Effects of topical retinol treatment of 80+ year old individuals. J Invest Dermatol, 110(4):599, 1998. Di W, Li XY, Datta S, Astrom A, Fisher GJ, Voorhees JJ, Xiao JH: Keratinocyte-specific retinoid regulation of human cellular retinoic acid binding protein-II gene (hCRABPII) promoter requires sufficient levels of retinoid receptors and an evolutionarily conserved DR1 RA-responsive element. J Invest Dermatol, 110(4):494, 1998. Chung JH, Lin JY, Varani J, Kang S, Fisher GJ, Voorhees JJ: Increased stress-activated and decreased growth factor-activated MAP kinase activities lead to collagen deficiency and reduced cell growth in skin of elderly persons. J Invest Dermatol, 110(4):592, 1998. Boudjelal M, Wang ZQ, Voorhees JJ, Fisher GJ: Ultraviolet irradiation blocks retinoid signaling in human skin through proteasome-mediated degradation of nuclear retinoid receptors. J Invest Dermatol, 110(4):488, 1998. Li XY, Xiao JH, Fisher GJ, Voorhees JJ: Proteasome inhibitors enhance vitamin D3 signaling via inhibiting degradation of vitamin D3 receptors in human keratinocytes. J Invest Dermatol, 110(4):676, 1998. Lin JY, Wan YS, Bata-Csorgo Z, Talwar HS, Kang S, Voorhees JJ, Fisher GJ: Ultraviolet irradiation rapidly activates cell surface receptors and three distinct MAP kinase modules in human skin in vivo. J Invest Dermatol, 110(4):474, 1998. Kang S, Fisher GJ, Duell EA, Wan YS, Varani J, Voorhees JJ: The antioxidant N-acetyl cysteine increases the content of the endogenous antioxidant glutathione and prevents UV-induction of matrix metalloproteinases in human skin in vivo. J Invest Dermatol, 1999.

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100. 101. 102.
Boudjelal M, Voorhees JJ, Fisher GJ: Retinoic acid stimulates ubiquitination and subsequent proteasome-mediated degradation of nuclear retinoid receptors in human keratinocytes: A novel mechanism for attenuation of retinoid signal transduction. J Invest Dermatol, 1999. Fisher GJ, Wang ZQ, Choi HC, Kang S, Voorhees JJ: Short wavelength UVB (290-300nm) and long wavelength UVA (360-400nm) most efficiently induce collagenase in human skin in vivo. J Invest Dermatol, 1999. Chung JH, Lee JH, Kang S, Wang ZQ, Fisher GJ, Voorhees JJ: Ultraviolet irradiation induces metalloproteinase in human skin in vivo. J Invest Dermatol, 1999. Choi HC, Bata-Csorgo Z, Wang ZQ, Kang S, Fisher GJ, Voorhees JJ: Ultraviolet irradation increases matrix metalloproteinase-8 protein in human skin in vivo. J Invest Dermatol, 1999. Wang ZQ, Wan YS, Voorhees JJ, Fisher GJ: UV activates NF-kB through an antioxidant-sensitive pathway that is independent of cytokines in human keratinocytes and skin in vivo. J Invest Dermatol, 1999. Li XY, Talwar HS, Fisher GJ, Voorhees JJ: c-Jun mediates UV-induced dermal damage by coordinately inducing collagen breakdown and inhibiting collagen synthesis. J Invest Dermatol, 1999. Varani J, Wang ZQ, Perone P, Fisher GJ, Voorhees JJ: Reduced collagen production by fibroblasts in photoaged skin in vivo is normalized in cultured fibroblasts from photoaged skin. J Invest Dermatol, 1999. Quan T, Fisher GJ: Functional characterization of keratinocyte-specific enhancer elements in the human protein kinase Ch promoter. J Invest Dermatol, 1999. Xu Y, Wan Y, Voorhees JJ, Fisher GJ: Activation of epidermal growth factor receptor by ultraviolet irradiation occurs via inhibition of membrane protein tyrosine phosphates by reactive oxygen species. J Invest Dermatol, 2000. Boudjelal M, Bucknell K, Fisher GJ, Voorhees JJ: Ultraviolet irradiation reduces glucocorticoid receptors in human skin in vivo. J Invest Dermatol, 2000.
108. Quan TH, He TY, Voorhees JJ, Fisher GJ: Ultraviolet irradiation alters transforming growth factor- and Smad7 expression in human skin in vivo. J Invest Dermatol, 2000. 109. He TY, Quan TH, Voorhees JJ, Fisher GJ: UV irradiation blocks cellular responses to transforming growth factor- through downregulation of its type-II receptor and induction of Smad7. J Invest Dermatol, 2000. 110. Wan YS, Wang ZQ, Shao Y, Voorhees JJ, Fisher GJ: Ultraviolet irradiation activates the PI 3kinase/AKT(PKB) survival pathway in human skin in vivo. J Invest Dermatol, 2000. 111. Varani J, Datta SC, Wang ZQ, Shao Y, Fisher GJ, Voorhees JJ: Reduced collagen production by fibroblasts in photoaged skin is normalized in culture. J Invest Dermatol, 2000. 112. Kang S, Wan YS, Lee JH, Chung JH, Talwar H, Choi, HC, Fisher GJ, Voorhees JJ: Isoflavone genistein blocks ultraviolet irradiation-induced epidermal growth factor-receptor activation, Mitogenactivated protein kinase activity and matrix metalloproteinase gene expression in human skin in vivo. J Invest Dermatol, 2000. 113. Xu G, Wang ZQ, Wan YS, Shao Y, Voorhees JJ, Fisher GJ: Ultraviolet Irradiation Reduces NF-B Inhibitor IB- Protein Levels Thereby Activating NF-B and Upregulating NF-B-regulated Proinflammatory Cytokines in Human Skin in Vivo. J Invest Dermatol, 2001.

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114. He T, Quan T, Fisher GJ, Voorhees JJ: Ultraviolet Irradiation Inhibits Expression of Connective Tissue Growth Factor (CTGF) in Human Skin in vivo and in Human Skin Fibroblasts. J Invest Dermatol, 2001. 115. Wang HQ, Wan YS, Voorhees JJ, Fisher GJ: Activation of PI-3-kinase/Akt Pathway Protects Human Keratinocytes from Ultraviolet Irradiation-Induced Apoptosis. J Invest Dermatol, 2001. 116. Quan T, He T, Voorhees JJ, Fisher GJ: UV Irradiation Inhibits Procollagen Synthesis by DownRegulating the TGF- Type-II Receptor in Human Skin Fibroblasts. J Invest Dermatol, 2001. 117. Xu Y, Tan L, Wan Y, Kang S, Voorhees JJ, Fisher GJ: Oxidative Inhibition of Membrane-associated Protein Tyrosine Phosphatase Activates EGF-Receptors, which are Critical Mediators of the UV Responses in Human Keratinocytes. J Invest Dermatol, 2001. 118. Varani J, Zeigler M, Kang S, Fisher GJ, Voorhees JJ, Stoll SW, Elder JT: HB-EGF Activation of Keratinocyte ErbB Receptors Mediates Epidermal Hyperplasia, A Common Side Effect of Retinoid Therapy. J Invest Dermatol, 2001. 119. Fisher GJ, Quan T, He T, Voorhees JJ: Ultraviolet irradiation down-regulates type II TGF- receptors resulting in inhibition of connective tissue growth factor-dependent type I procollagen gene expression in human skin in vivo and human skin fibroblasts. Eup Soc Dermatol Res, 2001. 120. Varani J, Perone P, Fligiel SEG, Fisher GJ, Voorhees JJ: INHIBITION OF COLLAGEN PRODUCTION IN PHOTODAMAGE: Collagen fragments generated by matrix metalloproteinase-1 (MMP-1) and cleared by MMP-9 inhibit procollagen synthesis by skin fibroblasts. J Invest Dermatol, 2002. 121. Kafi R, Quan TH, Fisher GJ, Kang S, Voorhees JJ: Topical Retinol Prevents Acute UV Irradiationinduced Collagen Degradation and Increases Procollagen I in Photoaged Human Skin in vivo. J Invest Dermatol, 2002. 122. Kang S, Cho S, Burger J, Chung J, Fisher GJ, Voorhees JJ: NF-B is activated and proinflammatory cytokines and matrix degrading enzymes are induced in inflammatory acne lesions in vivo. J Invest Dermatol, 2002. 123. He T, Quan TH, Fisher GJ, Voorhees JJ: Retinoid Induction of Transforming Growth Factor-1 and Connective Tissue Growth Factor: Major Regulators of Collagen Synthesis, in Aged and Photoaged Human Skin in vivo. J Invest Dermatol, 2002. 124. Xu Y, Voorhees JJ, and Fisher GJ: Epidermal Growth Factor Receptor Activation is a Critical Mediator of Multiple UV Reponses in Human Keratinocytes. J Invest Dermatol, 2002. 125. Quan TH, He T, Shao Y, Voorhees JJ, and Fisher GJ: Elevated Expression and Retinoid Regulation of Cyr61 in Chronologically Aged, Photoaged, and UV-irradiated Human Skin in vivo. J Invest Dermatol, 2002. 126. Varani J, Brennan M, Bhatti H, Nerusu K, Bhagavathula N, Fisher GJ, Kang S, Voorhees JJ: Collagen degradation in UV-exposed human skin: MMP-1 is the major collagenolytic enzyme and high molecular weight fragments are the major degradation products. J Invest Dermatol, 2003.

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127. Quan TH, Voorhees JJ, Fisher GJ: Ultraviolet irradiation induction of Smad7 via activation of transcription factor AP-1 contributes to loss of procollagen gene expression in human skin fibroblasts. J Invest Dermatol, 2003. 128. Orringer J, Fisher GJ, Kang SW, Hammerberg C, Johnson T, Voorhees JJ: Molecular mechanisms of connective tissue remodeling induced by CO2 laser resurfacing of human skin in vivo. J Invest Dermatol, 2003. 129. He T, Quan TH, Voorhees JJ, Fisher GJ: Cystein-rich protein (CYR61), a mediator of collagen homeostasis, is elevated in chronologically aged, photoaged, and UV-irradiated human skin in vivo. J Invest Dermatol, 2003. 130. Xu Y, Shao Y, Voorhees JJ, Fisher GF: Ultraviolet Irradiation Induces Epidermal Growth Factor Receptor Nuclear Translocation in Human Keratinocytes. J Invest Dermatol, 2003. 131. Fisher GJ, Quan TH, He TY, Shao Y, Voorhees JJ: Ultraviolet Irradiation Activates NF- Pathway via Association of IB Kinase-/NEMO with IB kinase- and IB- in Human Keratinocytes. J Invest Dermatol, 2003. 132. Cho S, Kang S, Fisher GJ, Voorhees JJ: Wrinkles effacement by topical tretinoin is associated with an increase in the thickness of papillary dermal repair zone in human skin in vivo. J Invest Dermatol, 2003. 133. Kafi R, Schumacher W, Cho S, Kwack H, Hanft V, Neal J, Fisher GJ, Voorhees JJ, Kang S: Topical retinol improves fine wrinkles of natural/chronological aging. J Invest Dermatol, 2003. 134. Kang S, Cho S, Kafi R, Ratanatharathorn V, Voorhees JJ, Fisher GJ: Ultraviolet A1 is an effective antifibrotic phototherapy for scleroderma, and sclerodermoid graft-versus-host disease. J Invest Dermatol, 2003. 135. Fisher GJ, Quan T, He TH, Shao Y, Voorhees JJ: Activation of P38 MAP kinase by ultraviolet irradiation limits early activation of NF-B, which is required for induction of primary cytokines IL1 and TNF- in human keratinocytes. Eup Soc Dermatol Res, 2004. 136. Ritti L, Varani J, Fisher GJ, Voorhees JJ: Retinoid-Induced epidermal hyperplasia is mediated by epidermal growth factor receptor activation via specific induction of its ligands heparin binding-EGF and amphiregulin in human skin in vivo. J Invest Dermatol, 2004. 137. Quan TH, He T, Shao Y, Voorhees JJ, Fisher GJ: Elevated cystein-rich 61 (CYR61/CCN1) mediates reduced collagen production in chronologically-aged human skin fibroblasts in vitro and in vivo. J Invest Dermatol, 2004. 138. He TY, Quan TH, Voorhees JJ, Fisher GJ: UV irradiation reduces type I procollagen production by transcriptional repression through a 90 base pair sequence in the promoter of TGF- type II receptor in human skin fibroblasts. J Invest Dermatol, 2004. 139. Xu Y, Voorhees JJ, Fisher GJ: UV irradiation activates epidermal growth factor receptor via reactive oxygen-mediated inhibition of receptor type protein tyrosine phosphatase. J Invest Dermatol, 2004. 140. Karimipour DJ, Kang SW, Hamilton T, Johnson TM, Orringer JS, Hammerberg C, Fisher GJ, Voorhees JJ: Aluminum oxide microdermabrasion induces transcription factors, cytokines, and matrix

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metalloproteinases that function in dermal extracellular matrix remodeling in human skin in vivo. J Invest Dermatol, 2004. 141. Kang S, Cho S, Daley T, Garza L, Kafi R, Wang R, Voorhees J, Fisher G: Induction of matrix metalloproteinases and inhibition of procollagen synthesis in human skin in vivo by ultraviolet A1 irradiation is profoundly diminished by skin pigmentation. J Invest Dermatol, 2004. 142. Garza LA, Wang R, Cho S, Kafi R, Fisher GJ, Voorhees JJ, Kang S: Sustained anti-fibrotic responses to a single UVA1 exposure are attenuated by subsequent exposures in human skin in vivo-implications for phototherapy for fibrotic skin diseases. J Invest Dermatol, 2004. 143. Varani J, Kang S, Fisher GJ,Voorhees JJ: Reduced fibroblast interaction with intact collagen as a mechanism for depressed collagen synthesis in photodamaged skin. J Invest Dermatol, 2004. 144. Xu Y, Tan L-J, Grachtchouk V, Voorhees JJ, Fisher GJ: Receptor type protein phoshpatase- attenuates EGFR signaling by specifically dephosphorylatind Shr adaptor protein in human keratinocytes. J Invest Dermatol, 2005. 145. Riit L, Shao Y, Voorhees JJ, Fisher GF: Human skin expresses both estrogen receptor alpha and beta, and responds to topical estradiol by production of type I procollagen expression. J Invest Dermatol, 2005. 146. Kwak HR, Fisher GJ, King A, Voorhees JJ, Sang S: CYP26 inducibility by retinoic acid does not determine acne patients clinical response to oral isotretinoin. J Invest Dermatol, 2005. 147. He T, Quan T, Voorhees JJ, Fisher GJ: Acute oxidative stress causes long-lived reduction of type I collagen and increased collagenase in human skin fibroblasts. J Invest Dermatol, 2005. 148. Garza L, Cho S, Daley T, Kafi R, Wang R, Voorhees JJ, Fisher GJ, Kang S: Failure to induce matrix metalloproteinases in pigmented human skin in by UVA1 is overcome by high dose UVB/A2. J Invest Dermatol, 2005. 149. Ritt L, Kansra Y, Li Y, Stoll S, Michael LE, Shao Y, Boyd C, Johnson T, Fisher GJ, Elder JT: Differential autocrine ErbB signaling in SCC vs BCC. J Invest Dermatol, 2005. 150. Quan T, Voorhees JJ, Fisher GJ: TGF-/SMAD pathway plays a crucial role in basal expression of type I procollagen in human skin fibroblasts. J Invest Dermatol, 2005. 151. Fisher GJ, Quan T, Kang S, Voorhees JJ: Connective Tissue Growth Factor: a Key Regulator of Collagen Production is Reduced in Aged Human Skin in vivo. European Soc Dermatol Res, 2005. 152. Xu Y, Tan LJ, Grachtchouk V, Voorhees JJ, Fisher GJ : Receptor-type prptein-tyrosine phosphatasekappa regulates growth factor receptor signaling and proliferation in human keratinocytes. J Invest Derm, 2006. 153. Quan T, He T, Shao Y, Kang S, Voorhees JJ, Fisher GJ: Elevated cystein-rich protein 61 (CYR61/CCN1), mediates aberrant collagen homestasis in chronologically-aged and photoaged human skin. J Invest Dermatol, 2006. 154. Riite L, Voorhees JJ, Fisher GJ: Genomic actions of estrogen receptors-alpha and beta are limited by their low levels of expression in primary human dermal fibroblasts. J Invest Dermatol, 2006.

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155. He T, Quan T, Voorhees JJ, Fisher GJ: Gene expression profiles of oxidative stress-induced and replication-induced senescent adult human dermal fibroblast. J Invest Dermatol, 2006.

Updated 10/25/2006