A large, user-friendly, clear text navigational display ensures easy, trouble-free operation and even allows you to tailor a wide range of settings, such as buzzer volume and display brightness, to your requirements. Even the language shown in the display can be changed!
Navitronic retractable controls with turn and press mechanism, user friendly clear text navigational display Recommended temperatures and actual temperature display Temperatures adjustable between 40C and 100C Programmable settings (buzzer volume and duration, language, display On/Off, recommended temperatures and display contrast/brightness)
Electronic clock with time of day display, minute minder, programme delay: set the start time and duration or end time and duration with automatic switch-off, 200 hour battery back-up
System lock, in-operation lock, door contact switch, enhanced vapour cooling and venting system, cool front
Quick release side runners, flush floor heater for a reduction in condensed water in cabinet after cooking, descaling programme with reminder, fault messages, water container level indication
2 x perforated 0.9 litre and 1 x perforated 1.7 litre net capacity stainless steel containers, rack, drip tray, water tank with integrated heating element, cookbook
Perforated and solid stainless steel containers HKL 60 joining strip for installation with an oven, combi-oven, steam oven or coffee machine
Suitable for installation in a 60 cm wide tall or base unit, see Building-in diagrams for dimensions
* N.B. Base unit installation may not be suitable if there are small children in the home

DG 4080

DG 4080 Steam oven
Stainless steel with stainless steel handle Aluminium with aluminium handle Full-width tinted glazing 30 litre stainless steel oven interior with 4 cooking levels External steam generator
Automatic programmes for over 130 food types, plus 30 user programmes and 4 standard programmes (Universal, Vegetables, Fish, Meat/Poultry) as well as reheating and defrosting Automatic menu cooking for 3 dishes at the same time 15 min. warming function at end of programme, steam reduction system before end of programme
The 30 litre capacity DG 4080 is 60 cm wide and is designed for installation in a tall or base* unit. This model offers high-end state of the art Navitronic sensor touch controls and a back-lit numerical key pad for the ultimate in good looks and user convenience. Programmes are selected via the sensor touch pads and settings can be altered very easily using the numerical key pad. It offers the same programmes and functionality as the DG 4060 with the added benefit of menu cooking. With this programme you are prompted to select up to three different types of dishes. The electronic controls calculate the cooking time for each and will prompt you when to place the next dish in the oven so your food is ready at the same time with the minimal amount of effort on your part!

Notes: Recess dimensions for built-in appliance (appliance dimensions are quoted for the DG 1050). 2) Take care when building appliance into a housing unit or into a wall to ensure that the unit or wall is able to support the appliance. 3) On this steam oven these functions are selectable by setting a temperature and a duration. N.B.: These appliances conform to European safety regulations and must be installed in accordance with IEE regulations by a competent person. 4) 350 mm niche height when fitted in a wall unit, 360 mm niche height when fitted in a tall unit

Steam oven DG 2661

Undercounter installation may not be suitable if there are young children in the home
Steam oven DG 4060/DG 4080
Steam oven DG 4060/DG 4080 Fitted above a single oven

DG 4064 L

1. Cut-out in fixed base for feeding water inlet and drainage hoses through Important planning tip: This appliance must be plumbed into the mains drinking water supply and to a drainage point. Please see connection details on the diagram regarding water inlet and outlet points.
1. Cut-out in fixed base for feeding water inlet and drainage hoses through 2. AB 45-7 optional extra Important planning tip: This appliance must be plumbed into the mains drinking water supply and to a drainage point. Please see connection details on the diagram regarding water inlet and outlet points.
DG 4064 L, water connection 1. Cut-out in fixed base for feeding water inlet and drainage hoses through 2. Position of electrical connection point (N.B. this should not be located behind the appliance in the UK) 250 x 80 mm connection cable, L = 2000 mm 3. Stopcock (cold water supply) 4. Water connection safety valve 5. Water inlet hose, L = 2500 mm, Can be extended up to a max. of 7500 mm 6. Second separate siphon 7. Do not connect drain hose here 8. Drain hose, L = 3000 mm, Can be extended (horizontally) to a max. of 7500 mm 9. The top end of the drain hose must not be higher than 500 mm where it connects to the odour trap

Coffee machines

Coffee: the ultimate cup Miele introduced the worlds first built-in coffee machine in 1999. Since then, the appeal of coffee has increased, and it has become much more than just a drink. Miele offers a range of coffee machines to suit any type of coffee lover. Choose from the machine which grinds fresh beans for each cup, or the NESPRESSO machine, which uses sealed capsules. Whatever your taste, Miele offers a machine to suit.

KM 411 Electric grill

CSGP 400 Griddle
For use with KM 411. Ideal for drop scones, steak, fish etc. Smooth on one side and fluted on the other.

KM 408-2 Gourmet grill

COOKING ZONE
Hinged grill element Stainless steel drip tray, to be used with water or lava rock
Smooth surface contact grill 33 x 18 cm
Freely adjustable temperature control
Freely adjustable energy control

In operation light

Drain valve In operation light
N.B.: Due to excess smoke created when cooking
fatty foods over the lava rocks adequate extraction is essential. A high powered output extractor is strongly advised. Allow 650 mm between the grill and a cooker hood above.
N.B.: To ensure that the underside of the appliance
is not accessible after installation a protective shelf and a front panel need to be fitted underneath it if it is not installed above an oven.
See building-in diagrams and product information pages for exact appliance and cut-out dimensions as well as output levels

KM 403 Electric fryer

Ceramic control panel, stainless steel surround and rim

KM 412 Ceramic hob

Stainelss steel rim

KM 418 Induction hob

Cold oil zone and expansion rim Swing-up heating element Nickel plated wire basket with hanging hood and folding removable handle Black metal lid with chrome handle
1 HiLight zone which can be extended to take an oval dish

2 induction zones

Onset sensor controls Booster function for one zone 9-stage power level display
In operation light Residual heat indicator
Thermostatic temperature control, 100C to 200C
Residual heat indicator Drain valve In operation light
Indicators for on/off, auto heat-up, safety lock, booster function, no pan Residual heat indicators Automatic switch off, system lock, safety cut-out, fault indication, integrated cooling fan with automatic run-on

DA 449-4 Cooker hood

90 cm wide Stainless steel with glass canopy For independently mounting on the wall or building in between units Extraction or option of recirculation with charcoal filter Min. distance from hob: gas 650 mm/electric 450 mm
Active charcoal filter DKF 9, vent hose, wall vent kit, E-Cloth, DALF 249 glass shelf (max. load 4 kg/k lbs) DUW 10 conversion kit for recirculation mode

DA 249-4 EXT

As above, but with external motor (order separately). See External motors.

DA 5294 W Cooker hood

DA 279-4 Cooker hood
90 cm wide Stainless steel with amber or electric blue feature lighting Aluminium with electric blue feature lighting For independently mounting on the wall or building in between units Extraction or option of recirculation with charcoal filter Min. distance from hob: gas 650 mm/electric 450 mm

DA 289-4 Cooker hood

90 cm wide Stainless steel with glass canopy For independently mounting on the wall or building in between units Extraction model only Min. distance from hob to lower edge of glass: gas 365 mm/electric 365 mm
Double acting radial fan Two easily removable stainless steel grease filters, dishwasher safe Hob illumination via 2 x 20 W halogen lights, dimmable Telescopic chimney Ducted vertically or to rear
Electronic touch controls with LEDs for fan settings, on/off, hob illumination, feature lighting, run-on time (5/15 min), individual programming of number of working hours for grease/charcoal filters Three fan settings plus intensive
Electronic touch controls with LEDs for fan settings, on/off, hob illumination, run-on time (5/15 min), individual programming of number of working hours for grease filter Three fan settings plus intensive
Double acting radial fan Two easily removable stainless steel grease filters, dishwasher safe Hob illumination via 3 x 20 W halogen lights, dimmable Glass edge illumination via LEDs (no bulbs to change) Telescopic chimney Ducted vertically or to rear
Double acting radial fan Easily removable stainless steel grease filter, dishwasher safe Hob illumination via 4 x 10 W halogen lights, dimmable Telescopic chimney Ducted vertically or to rear
Vent hose, wall vent kit, E-Cloth

DA 5294 W EXT

As above, but with external motor (order separately). See External motors. Special order only.

DA 279-4 EXT

DA 289-4 EXT

DA 489-4 Cooker hood

90 cm wide Stainless steel with glass canopy For independently mounting on the wall or building in between units Extraction model only Min. distance from hob: gas 350 mm/electric 350 mm
Double acting radial fan Three easily removable stainless steel grease filters, dishwasher safe Hob illumination via 4 x 20 W halogen lights, dimmable Telescopic chimney Ducted vertically or to rear

Small removable vario insert with drop down spikes and hinged cup rack on the right

Removable bottle holder

Cutlery basket
G 606 SCi Plus, G 603 SCVi Plus G 975 SCi Plus G 1040 i, G 1180 Vi G 1140 SCi G 1220 SCi, G 1270 SCVi G 2530 SCi, G 2830 SCi, G 2570 SCVi, G 2870 SCVi
Miele dishwashers offer a range of different control options so you can find the one to suit your lifestyle and design requirements. They all feature Novotronic controls, which were developed and made in our own factories. Because they are fully electronic, there is less wear and tear to the control system. They also offer a wide range of intelligent programmes including special
programmes with user friendly names to make the chore of choosing the right programme a thing of the past. The appliances also use intelligent technology to adapt to circumstances and make the most economical use of electricity, water and salt.
The traditional range of dishwashers offers a simple, easy to use, rotary programme selector together with pushbutton controls for On/Off and Start. They also have
programme sequence indicator lights to let you know how the programme is progressing and check lights to remind you when to replenish the salt and rinse aid.
With the new dishwashers, the controls and display elements are positioned in the centre of the fascia panel for easy and logical programme selection. The controls on some models are set at an ergonomic angle making them extremely easy to read and use from a standing position.
These dishwashers offer a range of control types from simple selector button controls to rotary and selector button controls to models with selector buttons and a time left display. Going up the range, greater functionality is introduced, including a delay start function and a tab button to optimise the programme to the type of detergent being used.
Topping the range is a model with the large Navitronic Plus display and user friendly touch sensor controls. The display is in clear text and intuitively guides you through the programme selection process. The controls are easy to operate at a mere touch and being flush, are easy to keep clean. Wider ranging programme choice is also introduced including special programmes, many of which are named to suit the type
of load they are designed for such as plastics and pasta. Programme parameters can be tailored to include features such as a pre-wash or a soak, and you can even programme the display to list your favourites first. These models also introduce an Info button which will give you tips and guidance on what programme to use.
With the fully integrated models, the controls are discreetly concealed from view when you dont need to see them. The entry level model offers simple push button controls and check lights to remind you when to replenish the salt and rinse aid. Going up the range, a time left display is introduced together with a delay start option and a tab button to optimise the programme to the

44 dB(A) re 1pW in situ

G 2000 top-of-the-range integrated dishwasher
G 2830 SCi XXL integrated dishwasher
Angled fascia Available in stainless steel User friendly sensor pads Large Navitronic PLUS clear text display Info button for extra tips Unique cutlery tray with removable sections Salt reservoir in the door for easy access
PROGRAMMES Upper basket GOK 60.85
Pots & Pans 75C, Sensor wash, Sensor wash gentle, Quick wash 40C, Normal 55C Energy-save, Hygiene, Pre-wash

SPECIAL PROGRAMMES

Intensive 65C, Plastics, Fondue, Pasta, Tall items 45C, Tall items 65C, Glasses quick, Glasses warm, Without heater, Pre-wash 30C, Watersave
Height adjustable upper basket (GOK 60.85) Versatile lower basket (GUK 60.70 SC) Intelligent 2 in 1 / 3 in 1 Tab function Delay Start option Child resistant door lock Middle/lower spray arm fault indication Check filter indication Automatic load recognition AUTO Sensor Alternating spray arm for reduced water consumption Buzzer

42 dB(A) re 1pW in situ

XXL with more room to play To cater for the growing trend towards kitchens with a worktop height of 85 cm and above Miele offers a range of 85 cm high XXL model dishwashers with up to 14 place settings
G 1000 fully-integrated dishwashers
G 1180 Vi integrated dishwasher
All Miele 60 cm wide fullyintegrated dishwashers share the following features:
Fully integrated with concealed control panel User friendly selector buttons Cutlery basket

PROGRAMMES

Concealed stainless steel fascia They are supplied ready for fitting with a stainless steel panel (order separately see Accessories for details), or a door front (not supplied) to match your kitchen furniture
Pots & Pans 75C, Sensor wash 55-65C, Light soiling 50C, Quick wash 40C, Energy-save, Pre-wash
Height adjustable upper basket (GOK 60.15) Lower basket (GUK 60.10) ECO Sensor Buzzer

CONSUMPTION

Upper basket GOK 60.15
Fully electronic with PC Update function
13 litres water, 1.05 kWh electricity in Energy save programme
HEATING Lower basket GUK 60.10
G 1270 SCVi integrated dishwasher
Fully integrated with concealed control panel User friendly selector buttons Unique cutlery tray
Height adjustable upper basket (GOK 60.10) Lower basket (GUK 60.20 SC) AUTO Sensor Buzzer Time left display Intelligent 2 in 1 / 3 in 1 Tab function Delay start In-operation indicator light
Lower basket GUK 60.20 (SC)
G 2000 fully-integrated dishwashers
G 2570 SCVi integrated dishwasher
Height adjustable upper basket (GOK 60.75) Lower basket (GUK 60.70 SC) Automatic load recognition AUTO Sensor Alternating spray arm for reduced water consumption Buzzer Time left display Intelligent 2 in 1 / 3 in 1 Tab function Delay start option Glass care LED Spray arm indicator Check filter indicator In-operation indicator light

G 2530 SCi, G 2830 SCi

Niche height 870 mm Niche height 820 mm
Plinth height 35155 mm Plinth height 100220 mm

G 1270 SCVi, G 1180 Vi

G 2570 SCVi, G 2870 SCVi

G 606 SCi

G 603 SCVi

Miele Refrigeration

Whether it's design or functionality that you are looking for, the Miele refrigeration range offers a broad spectrum of products to suit a multitude of lifestyle needs. The attention to detail is exemplified by our desire to provide appliances of the highest quality, within which lie a host of features that create the perfect cool environment for your food and drinks. Design, convenience and functionality are the cornerstones of our philosophy, the essence of which is reflected throughout our entire range. Miele refrigeration, full of fresh thinking.

Designer refrigeration

In addition to the integrated refrigeration appliances shown in this brochure Miele also offer a range of freestanding designer stainless steel refrigeration appliances that are the ultimate in style and sophistication. These are described briefly below. For more information regarding these products please refer to the Miele Freestanding brochure. Wine Miele also offer a selection of freestanding wine units with both stainless steel and glazed fronts to ensure you wine gets the best possible treatment. Please ask for our special wine brochure.
Food centres Miele offers a wide range of side-by-side combination appliances giving you the flexibility to mix and match the features of your choice, such as fridge size, freezer size, PerfectFresh zone, Ice maker and wine cooler options.
Glass Light This exclusive fridge-freezer features stunning glass edge LED lighting which is incorporated into both the main appliance shelving and the door shelving. This produces a brilliant blue light and provides excellent visibility of the contents even when fully loaded. This model also includes dynamic cooling and an integrated ice-cube maker.
DesignLine range These striking American style fridge-freezers are fully clad in handcrafted stainless steel. The range includes a larder fridge and freezer, a larder fridge and wine cooler/ freezer and a huge 152 cm wide model with two side-by-side 70/30 fridge-freezers. Other features to be found in this range are Dynamic cooling, PerfectFresh and an Ice maker.

Cool controls

Creating the perfect environment for the storage of food is the main purpose of any refrigerator or freezer. Miele refrigeration utilises the latest technology in a range of control types to ensure that not only is the internal environment created as efficiently as possible, but that it is also maintained, thus ensuring food is stored in the best possible conditions.
The entry level appliances feature a simple rotary dial inside the appliance to set the required temperature range. Some of these appliances also offer a winter setting which can be activated to maintain the internal temperature of the appliance during periods of below average ambient temperatures.

Interior design Easy cleaning and adjustability are key factors to be considered when purchasing a new refrigeration appliance. All Miele appliances feature glass shelves manufactured from safety glass which has the additional benefit of helping maintain the interior temperature. The shelves can hold up to 25 kg and all are easily removed for cleaning purposes. A selected number of shelves in all Miele appliances are adjustable, which enable you to make best use of the space available. The majority of models also feature split shelves for added convenience.
Interior door shelving The Miele interior door shelving is made from high quality frosted plastic with chrome framing. All shelves are height-adjustable and are easily removed for cleaning. A covered dairy compartment with sliding lid protects the contents from transfer of odours. Interior lighting Lighting in the refrigerator section of Miele refrigeration appliances provide an effective uniform spread of light to enable a good view of the contents.
Freezer drawers Transparent freezer drawer fronts feature on the majority of Miele freezers. These allow a quick view of the contents without the need to pull out the drawer. A frozen food marker system enables a further indication of the drawer contents. Miele drawers are enclosed on all sides, which helps to maintain the drawer temperature when it is opened. They are easily removed for cleaning and are designed not to tip.

Integrated refrigerators

K 621 Ui-1 Larder refrigerator

K 622 Ui-1 Refrigerator

K 621 i-1 Larder refrigerator
Suitable partner for F 623 Ui-2 Fully integrated larder refrigerator with 157 l/ 5.5 cu ft usable space Door hinged right, convertible Fixed hinges, door mounted on appliance Front ventilation, no grille required in worktop
Temperature dial inside the appliance with settings from 17 Automatic defrosting

INTERIOR FITTINGS

Suitable partner for F 623 Ui-2 Fully integrated refrigerator with 133 l/ 4.7 cu ft usable space Fridge compartment with 116 l/4.1 cu ft usable space 4-star freezer compartment with 17 l/0.6 cu ft usable space Freezes 2 kg in 24 hours Door hinged right, convertible Fixed hinges, door mounted on appliance Front ventilation, no grille required in worktop
Suitable partner for F 311 i-6 Fully integrated larder refrigerator with 155 l/ 5.5 cu ft usable space Door hinged right, convertible Sliding hinges

Fully enclosed evaporator 7 high quality glass shelves, including 1 split shelf, 6 are height adjustable 2 vegetable compartments Chrome bottle rack Versatile door fittings with bottle rack and covered dairy compartment Interior light
On/Off dial on front of appliance with temperature settings from 14 Digital temperature display Super cool switch and indicator light Automatic defrosting (fridge only)
Fully enclosed evaporator 5 high quality glass shelves, including 1 split shelf, 4 are height adjustable 2 vegetable compartments Versatile door fittings with bottle rack and covered dairy compartment Ice cube tray Interior light

K 854 i-2 Refrigerator

K 581 iD Larder refrigerator
Side-by-side model for F 456 i-2 Fully integrated refrigerator with 228 l/8 cu ft usable space Fridge compartment with 178 I/6.3 cu ft usable space PerfectFresh zone with 50 l/1.8 cu ft usable space Door hinged right, convertible Fixed hinges, door mounted on appliance
Fully integrated larder refrigerator with 310 l/11.0 cu ft usable space Door hinged right, convertible Fixed hinges, door mounted on appliance
On/Off switch Electronic controls with temperature selector buttons Digital temperature display for refrigerator section Super Cool switch and indicator light

REFRIGERATOR

Temperature control inside the appliance with LED indicators Super cool control with indicator light On/Off rocker switch Automatic defrosting Dynamic cooling
Automatic defrosting Fully enclosed evaporator 5 high quality glass shelves including 1 split shelf, 4 are height adjustable 2 vegetable compartments Versatile door fittings with bottle rack and covered dairy compartment Interior light

PERFECTFRESH ZONE

Internal walls coated with anti-bacterial AgION 6 high quality glass shelves, including 1 split shelf 1 small sliding drawer 2 vegetable compartments, one with humidity regulator Versatile door fittings including bottle rack, all with chrome rails Interior light
2 pull-out compartments Upper compartment with up to 45% humidity Lower compartment with up to 90% humidity

4-STAR FREEZER

2 large non-tip sealed transparent drawers Shallow tray for flash freezing Removable glass cold plate between drawers Ice cube tray Frozen food marker system Freezes 8 kg in 24 hours
KF 680 i-2 Fridge-freezer
KF 888 iDN-1 Frost-free fridge-freezer
Fully integrated model with 245 l/8.6 cu.ft total usable space; fridge 136 l/4.8 cu ft, PerfectFresh zone 62 l/2.2 cu ft; freezer 47 l/1.6 cu ft Doors hinged right, convertible Sliding hinges
Fully integrated model with 268 l/9.4 cu ft total usable space; fridge 204 l/7.2 cu ft, freezer 64 l/ 2.2 cu ft Doors hinged right, convertible Sliding hinges
2 independently controlled compressors Temperature selector buttons with digital temperature display for fridge and freezer Super Cool switch with indicator light Super Freeze switch with indicator light Audible warning signal/display and OFF switch ON/OFF switches
Single compressor for fridge and freezer Temperature selector buttons with digital temperature display for fridge and freezer Super Cool switch with indicator light Super Freeze switch with indicator light Audible warning signal/display and OFF switch ON/OFF switches
Automatic defrosting (fridge only) Fully enclosed evaporator 4 high quality glass shelves including 1 split shelf, 3 are height adjustable 2 vegetable compartments Versatile door fittings with bottle rack and covered dairy compartment Interior light
2 pull-out compartments Upper compartment with up to 45% humidity Lower compartment with 4590% humidity
Dynamic cooling with on/off switch inside the appliance Automatic defrosting Fully enclosed evaporator 5 high quality glass shelves including 1 split shelf, 4 are height adjustable Chrome bottle rack 2 vegetable compartments Versatile door fittings with bottle rack and covered dairy compartment Interior light
2 large, sealed transparent non-tip drawers Open freezer tray, 2 cool packs, ice cube tray Frozen food marker system Freezes 10 kg in 24 hours
Frost-free system with automatic defrosting 3 large, sealed transparent non-tip drawers Removable cold plate between 2 drawers Open freezer tray, cool pack, ice cube tray Frozen food marker system Freezes 10 kg in 24 hours
KF 880 iN-1 Frost-free fridge-freezer
Fully integrated model with 231 l/8.1 cu ft total usable space; fridge 108 l/3.8 cu ft; PerfectFresh zone 60 l/2.1 cu ft; freezer 63 l/2.2 cu ft Doors hinged right, convertible Sliding hinges
Automatic defrosting Fully enclosed evaporator 3 high quality glass shelves including 1 split shelf, 1 is height adjustable 2 vegetable compartments Versatile door fittings with bottle rack and covered dairy compartment Interior light

176.53.79.5 177.2178.5556 108/3.8 60/2. 63/2. 180/A 328.5 v SNST
176.53.9 76.2 80.5 177.2178.5557 204/7. 59/2.30 2+2 150/A 335.8 v SNST
81.8 59.42.4 45. 114/4. 220240 0.13 B 292 v SNT
139.3 55.9 54.4 56.5 60.2 139.7141.3 56.056. 156/5. 220240 0.13 A+ 262.8 v SNT
Model no Design door hinged r = right, c = convertible, l = left Product colour Handle type Dimensions appliance Height (cm) Width (cm) Depth incl. distance from wall (cm) Net weight (kg) 1) Gross weight (packaged) (kg) Features Dynamic cooling Net wine capacity in litres/cu.ft No. of 0.75 l Bordeaux bottles No. of storage levels No. of telescopic shelves Automatic defrosting Technical data Electronic controls Alarm No. of compressors Noise levels in dB Voltage Amps Rated load Fuse rating Energy efficiency rating Energy consumption 2) Complies with safety regulations Radio/television suppressed Type of climate 3)
KWT 4154 UG-1 r/c glass front recess handle 81.886.8 59,126/4.(15/23) 220240 V 0.9 A 120 W 13 A 220 kWh SN-ST
Ensure that the unit is able to support the weight of the appliance when full Energy consumption per year was calculated according to DIN EN 153 1990. Tests were made on a 220 V/50 Hz appliance. 3) SN = suitable for normal climate with surrounding temperatures of 10C to 32C N = suitable for surrounding temperatures of 16C to 32C SN-T = suitable for surrounding temperatures of 10C to 43C SN-ST = suitable for surrounding temperatures of 10C to 38C N.B. This appliance conforms to European safety regulations and must be installed in accordance with IEE regulations by a competent person.
F 623 Ui-2 K 621 Ui-1, K 622 Ui-1

F 311 i-6 K 621 i-1

K 845 i-1
F 456 i-2 K 855 iD-1, K 856 i-1

K 854 i-2

K 581 iD

KD 683 i-3

KF 680 i-2
KF 880 iN-1 KF 888 iDN-1, KF 889 iDNE-1
A 5 x 40 cm cut-out is needed to achieve a min. 200 cm2 ventilation gap.

Laundry

Miele offer a range of laundry appliances for integration into a run of kitchen units. These appliances come without a front panel and need to be fitted with a furniture panel to suit your kitchen furniture.

Energy consumption

Spin efficiency
T 4839 Ci condenser tumble dryer
6 kg capacity honeycomb drum White or stainless steel fascia panel Left hand hinged Clear text LCD Plus display Soft touch controls for: Cottons, Minimum iron, Delicates, Woollens handcare, Smoothing, Automatic, Shirts, Denim, Cool air, Warm air, Standard pillows, Large pillows, Silks handcare, Sportswear, Outerwear, Proofing, Cottons hygiene, Minimum iron hygiene, Timed drying hygiene Extra options: Low temperature, Short, Anti-crease and Buzzer Delay start selector button In operation/system lock

W 2209 i washing machine

5 kg capacity honeycomb drum White fascia panel Right hand hinged Time left display Single programme selector dial for: Cottons, Minimum iron, Delicates, Silks, Woollens, Quick wash, Automatic, Starch, Separate rinse, Drain/Spin Extra options: Intensive, Pre-wash, Soak, Water plus Maximum spin speed 1400 rpm
W 2839 i WPM washing machine
5 kg capacity honeycomb drum White or stainless steel fascia panel Right hand hinged Clear text LCD Plus display Soft touch controls for: Cottons, Minimum iron, Delicates, Silks, Woollens, Automatic, Shirts, Denim, Express, Hygiene, Starch, Dark garments, Curtains, Pillows, Sportswear, Outerwear, Proofing, Separate rinse, Drain/Spin Extra options: Short, Pre-wash, Soak, Water plus, Rinse-hold, Extra rinse Load/Detergent selector buttons Delay start selector button In operation/system lock Maximum spin speed 1600 rpm
WT 2679 i WPM washer dryer
5 kg capacity honeycomb drum 2.5 kg capacity for drying White fascia panel Right hand hinged Halogen drum lighting Clear text LCD Plus display Selector switch for washing or drying or for washing followed by drying Single programme selector dial Programmes for washing and drying: Cottons, Minimum iron, Delicates, Silks, Woollens, Express, Automatic, Dark garments, Shirts, Denim, Sportswear, Outerwear, Proofing Extra washing programmes: Curtains, Starch, Separate rinse, Drain/Spin Extra drying programmes: Warm air, Cool air, Smoothing and Rinse out fluff for drying Extra options: Short, Pre-wash, Soak, Water plus Delay start, Load/Detergent, Low temperature and Buzzer selector buttons Maximum spin speed 1600 rpm
Miele Integrated washing machines
Model Design Door hinging Colour options, control panel Matching dryer and stacking kit Matching condenser dryer Stacking kit for matching dryer (with shelf) Stacking kit for matching dryer (without shelf) Performance/Consumption data1) Energy efficiency/Wash performance/Spin efficiency Water consumption Electricity consumption Standard programme duration2) Residual moisture at maximum spin speed Spin Speed Options Minimum rpm W 2209 i W 2839 i WPM Right only White or stainless steel T 4839 Ci WTV 410 WTV 412 A+/A/B 45 0.85 116/59 50% A+/A/A 42 0.85 116/59 44% 400 in 100 rpm steps 1600 / / / 24 h / / / // / / / / / / / / / / 82 (+0.4/0.4)/59.5/57.169/1.6 1.1.5 1/ / // / / / / / / / / / / / 1

litres kWh min

Maximum rpm Rinse and hold/without spin Controls & Display Backlit dial/Touch buttons Small time left display/Plus LCD Display Delay start Buzzer option Programme sequence indication Excess detergent indication Features Vitreous direct enamel front/sides Removable front and side panels Unique Miele Honeycomb drum Anticrease action Power LED drum lighting Brushless Professional Motor Standard Wash Programmes Automatic (40 C) Cottons (30 C95 C) Minimum Iron (30 C60 C) Delicates (Cold40 C) Handwash/Woollens (Cold40 C) Handwash/Silks easy care (30 C) Quick or Express wash (40 C) Special Wash Programmes Denim (Cold40 C) Shirts (Cold60 C) Dark garments (40 C) Outerwear (Cold40 C)/Sportswear Curtains Cottons Hygiene (6095 C)/Pillows/Pillows Hygiene (6095 C) Proofing/Starch Separate rinse/drain and spin Additional Programme Options Standard running times with Short option Short running times with Intensive option Soak option/with direct time adjustment PreWash/Water plus Programmable options Choice of different languages Water Plus System for allergy sufferers Gentle action/Soak time Buzzer volume/keypad tones Energysaving standby mode Display contrast/brightness Safety features Water Control/Metal hose Waterproof System Check water drain/intake indication Automatic safety door lock/programme lock Inoperation/system lock Fault diagnosis programme Emergency door release Easy access manual drain Water inlet filter Dimensions and Weight Capacity kg Height/Width/Depth (inc. distance from wall) cm Depth with door open cm Stacked height: WTV with/without shelf cm Net weight kg Electricity and Water Connections Voltage (50 Hz) V Fuse rating A Power cable with fused plug m Connection to cold water via pressure hose with 3/4 inch (19 mm) threaded union m Water supply pressure min.max. bar Drain connection hose m Maximum drain pump height/length m Radio, TV & mains interference suppressed Operating instructions and guarantee

WT 2679 i WPM 1 kg kg cm cm cm cm kg V A kW m m bar m m 5 2.59.5 57.13 2.3 1.5 1.1.5 1/5
litres litres kWh kWh min
According to EN 60456 and EN 61121 tested in Cottons 60C and Cottons Normal Wash load 5 kg, drying load 2.5 kg 2) These programmes can also be set for timed drying for periods of between 15 minutes and 2 hours N.B. This appliance conforms to European safety regulations and must be installed in accordance with IEE regulations by a competent person.

Lets do lunch

Lets do lunch If you cannot make up your mind about which cooking appliances to choose, why not attend a Lets Do Lunch day in our Experience Centre and see the appliances in action for yourself? Our team of Home Economists will take you through all the benefits of Mieles excellent appliances with an entertaining cookery demonstration. The delicious results will be served for lunch and theres plenty of opportunity for asking questions. If you would like to join us, please ask your dealer for details, or ring Miele on 01235 233191.
Why not visit the fabulous new Experience Centre in Abingdon, Oxfordshire. There is no better place to get hands on experience with our appliances. Spread over two floors, covering 18,000 sq. ft. the centre is the largest Miele showroom and training facility outside Germany.
You can now see Miele professional equipment, domestic appliances and furniture all under one roof. The Centre also has state of the art presentation facilities, a live demonstration theatre and active kitchen. There is an extensive schedule of Lets do Lunch days to assist in your purchasing decisions theres even a relaxing Nespresso coffee bar for an informal chat. To make an appointment please call 01235 233191
Miele Company Ltd. Fairacres, Marcham Road, Abingdon, Oxon, OX14 1TW Tel: (01235) 554455 Telefax: (01235) 554477 Internet: www.miele.co.uk E-mail: info@miele.co.uk
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VSL#3 Literature

Original Articles

CLINICAL STUDIES

Ulcerative Colitis:
Tursi A., Brandimarte G., Papa A., Giglio A., Elisei W., Giorgetti GM, Forti G., Morini S., Hassan C., Pistoia MA., Modeo ME, Rodino S., D Amico T., Sebkova L., Sacca N., Di Giulio E., Luzza F., Imeneo M., Larussa T., Di Rosa S., Annese V., Danese S. and Gasbarrini A. Treatment of Relapsing Mild-to-Moderate Ulcerative Colitis With the Probiotic VSL # 3 as Adjunctive to a Standard Pharmaceutical Treatment: A Double-Blind, Randomized, Placebo-Controlled Study Am J Gastroenterol.105:2218-27 (2010) Ng S.C., Plamondon S., Kamm M.A., Hart A.L., Al-Hassi H.O., Guenther T., Stagg A.J. Knight S.C.Immunosuppressive Effects via Human Intestinal Dendritic Cells of Probiotic Bacteria and Steroids in the Treatment of Acute Ulcerative Colitis Inflamm Bowel Dis. 16:1286-98 (2010) Sood A., Midha V., Makharia GK., Ahuja v., Singal D., Goswami P. and Tandon RK. The probiotic preparation, VSL#3 induces remission in patients with mild-to-moderately avtive ulcerative colitis. Clin Gastroenterol Hepatol 11:1202-9 (2009) Hien H.Q, deBruyn J., Guan L., Diaz H., Li M., Girgis S., Turner J., Fedorak R., Madsen K. Probiotic Preparation VSL#3 Induces Remission in Children with Mild to Moderate Acute Ulcerative Colitis: A Pilot Study Inflamm Bowel Dis 15: 760-Miele E, Pascarella F, Giannetti E, Quaglietta L, Baldassano R, Staiano A. Effect of a Probiotic Preparation (VSL#3) on Induction and Maintenance of Remission in Children with Ulcerative Colitis. Am J Gastroenterology 104:437-443 (2009) Tursi A, Brandimarte G, Giorgetti GM, Elisei W, Aiello F Balsalazide and/or high-potency probiotic mixture (VSL#3) in maintaining remission after attack of acute, uncomplicated diverticulitis of the colon Int J Colorectal Dis 22:1103-8 (2007) Karimi O, Pena AS, van Bodegraven AA. Probiotics (VSL#3) in arthralgia in patients with ulcerative colitis and Crohn's disease: A pilot study. Drugs Today 41:453-9 (2005) Tursi A., Brandimante G, Giorgetti GM, Elisei M. Beclometasone Diproprionate Plus VSL#3 for the Treatment of Mild to Moderate Diverticular Colitis: An Open Pilot Study. J Clin Gastroenterol 39:644-5 (2005) Bibiloni R., Fedorak RN, Tannock GW, Madsen KL, Gionchetti P, Campieri M, DeSimone C, Sartor RB. VSL#3 Probiotic-Mixture Induces Remission in Patients with Active Ulcerative Colitis. Am J Gastroenterol 100:1539-46 (2005)
Tursi A., Brandimarte G, Giorgetti GM, Forti G, Mondeo ME, Gigliobianco A. Low dose balsalazide plus a high potency probiotic preparation is more effective than balsalazide alone or mesalazine in the treatment of acute mild to moderate ulcerative colitis. Med Sci Monit 10:PI126-131 (2004) Venturi A, Gionchetti P, Rizzello F, Johansson R, Zucconi E, Brigidi P, Matteuzzi D, Campieri M, Impact on the Composition of the Faecal Flora by a New Probiotic Preparation: Preliminary Data on Maintenance Treatment of Patients With Ulcerative Colitis. Aliment Pharmacol Ther 13:1103-1108 (1999)

Pouchitis:

Friederich P., Verschuur J., van Heumen B.W.H., Roelofs H.M.J., Berkhout M., Nagtegaal I.D., van Oijen M.G.H.,. van Krieken Johannes, Peters W.H.M. and Nagengast F.M. Effects of intervention with sulindac and inulin/VSL#3 on mucosal and luminal factors in the pouch of patients with familial adenomatous polyposis Int J Colorectal Dis 2011 Turroni S., Vitali B., Candela M., Gionchetti P., Rizzello F., Campieri M., Brigidi P. Antibiotics and probiotics in chronic pouchitis: A comparative proteomic approach World J Gastroenterol 16: 3041 (2010) Pronio A, Montesani C, Butteroni C, Vecchione S, Mumolo G, Vestri A, Vitolo D, Boirivant M Probiotic administration in patients with ileal pouch-anal anastomosis for ulcerative colitis is associated with expansion of mucosal regulatory cells Inflamm Bowel Dis 14:662-668 (2008) Gionchetti P, Rizzello F, Morselli C, Poggioli G, Tambasco R, Calabrese C, Brigidi P, Vitali B, Straforini G, Campieri M High-dose probiotics for the treatment of active pouchitis Dis Colon Rectum 50(12):2075-84 (2007) Kuehbacher T, Ott SJ, Helwig U, Mimura T, Rizzello F, Kleessen B, Gionchetti P, Blaut M, Campieri M, Folsch UR, Kamm MA, Shreiber S. Bacterial and fungal microbiota in relation to probiotic therapy (VSL#3) in pouchitis Gut 55:833-41 (2006) Mimura T, Rizzello F, Helwig U, Poggioli G, Schreiber S, Talbot IC, Nicholls RJ, Gionchetti P, Campieri M, Kamm MA. Once Daily High Dose Probiotic Therapy (VSL#3) for Maintaining Remission in Recurrent or Refractory Pouchitis. Gut 53:108-114 (2004) Gionchetti P, Rizzello F, Helwig U, Venturi A, Lammers KM, Brigidi P, Vitali B, Poggioli G, Miglioli M, Campieri M. Prophylaxis of Pouchitis Onset with Probiotic Therapy: a Double-blind, PlaceboControlled Trial. Gastroenterology 124:1202-09 (2003) Ulisse S, Gionchetti P, DAlo` S, Russo FP, Pesce I, Ricci G, Rizzello F, Helwig U, Cifone MG, Campieri M, De Simone C. Expression of Cytokines, Inducible Nitric Oxide Synthase and Matrix Metalloproteinases in Pouchitis: Effects of Probiotic Treatment. Am J Gastroenterology 96:26912699 (2001)

Gionchetti P, Rizzello F, Venturi A, Brigidi P, Matteuzzi D, Bazzocchi G, Poggioli G, Miglioli M, Campieri M, Oral Bacteriotherapy as Maintenance Treatment in Patients With Chronic Pouchitis: a Double Blind, Placebo-Controlled Trial. Gastroenterology 119:305-309 (2000)
Guandalini S. et al., VSL#3 improves symptoms in children with irritable bowel syndrome. Results of an international, randomized, placebo-controlled, double-blinded, cross-over study. J Pediatr Gastroenterol Nutr. 51:24-34 (2010) Kim HJ, Vazquez Roque MI, Camilleri M, Stephens D, Burton DD, Baxter K, Thomforde G & Zinsmeister AR. A randomized controlled trial of probiotic combination VSL#3 and placebo in irritable bowel syndrome with bloating. Neurogastroenterol Motil 17:110 (2005) Kim HJ, Camilleri M, Mc Kinzie S, Lempke MB, Burton DD, Thomforde GM, Zinsmeister AR. A Randomized, Controlled Trial of a Probiotic, VSL#3, on Gut Transit and Symptoms in Diarrheapredominant Irritable Bowel Syndrome. Alim Pharmacol Ther 17:895-904 (2003) Brigidi P, Vitali B, Swennen E, Bazzocchi G, Matteuzzi D. Effects of Probiotic Administration Upon the Composition and Enzymatic Activity of Human Fecal Microbiota in Patients With Irritable Bowel Syndrome or Functional Diarrhea. Res Microbiol 152:735-471 (2001)

Liver diseases:

Tandon P., Moncrief K., Madsen K., Arrieta M.C., Owen R. J., Bain V.G., Wong W.W., Ma M. M. Effects of probiotic therapy on portal pressure in patients with cirrhosis: a pilot study. Liver Int. 29:1110-5 (2009) Loguercio C, Federico A, Tuccillo C, Terracciano F, DAuria M V, De Simone C, Del Vecchio Blanco C. Beneficial effects of a probiotic VSL#3 on Parameters of liver dysfunction in chronic liver disease. J Clin Gastroenterol 39:540-3 (2005)
Chemotherapy/Radiotherapy:
El-Atti S. Abd, Wasicek K., Mark S., Hegazi R. Use of Probiotics in the management of chemotherapy- Induced Diarrhea: A Case Study. J of Parenteral and Enteral Nutrition (2009) Bowen JM, Stringer AM, Gibson RJ, Yeoh ASJ, Hannam S, Keefe DMK VSL#3 probiotic treatment reduces chemotherapy-induced diarrhea and weight loss Cancer Biol Ther 6:1-6 (2007) Delia P, Sansotta G, Donato V, Frosina P, Messina G, De Renzis C, Famularo G Use of probiotics for prevention of radiation-induced diarrhea World J Gastroenterol 13:912-915 (2007) Delia P, Sansotta G, Donato V, Messina G, Frosina P, Pergolizzi S, De Renzis C, Prophylaxis of Diarrhoea in Patients Submitted to Radiotherapeutic Treatment on Pelvic District: Personal Experience. Dig Liver Dis 34:S84-86 (2002)
Delia P, Sansotta G, Donato V, Messina G, Frosina P, Pergolizzi S, De Renzis C. Prevention of Radiation-Induced Diarrhea With High-Potency Probiotic Preparation. Am J Gastroenterol. 97:13-15 (2002)
Alberda C, Gramlich L, Meddings J, Field C, McCargar L, Kutsogiannis D, Fedorak R, Madsen K Effects of probiotic therapy critically ill patients: a randomized, double-blind, placebo-controlled trial Am J Clin Nutr 85:816-23 (2007) Frohmader Terence J., Chaboyer Wendy P., Robertson Iain K. and Gowardman John Patients Given the Multispecies Probiotic VSL#3: A Pilot Trial Decrease in Frequency of Liquid Stool in Enterally Fed Critically ill Am J Crit Care 19: 1-11 (2010)

Clinical studies in Pediatrics:
Hien H.Q, deBruyn J., Guan L., Diaz H., Li M., Girgis S., Turner J., Fedorak R., Madsen K. Probiotic Preparation VSL#3 Induces Remission in Children with Mild to Moderate Acute Ulcerative Colitis: A Pilot Study Inflamm Bowel Dis 15: 760-Miele E, Pascarella F, Giannetti E, Quaglietta L, Baldassano R, Staiano A. Effect of a Probiotic Preparation (VSL#3) on Induction and Maintenance of Remission in Children with Ulcerative Colitis. Am J Gastroenterology 104:437-443 (2009)

Rotavirus

Dubey AP. et al. Use of VSL#3 (a new high concentration probiotic mixture) in the treatment of childhood diarrhea with specific reference to Rotavirus Diarrhea J Clin Gastroenterol. Suppl 3 Pt 1:S126-9.
Guandalini S. et al., VSL#3 improves symptoms in children with irritable bowel syndrome. Results of an international, randomized, placebo-controlled, double-blinded, cross-over study. J Pediatr Gastroenterol Nutr. 51:24-34 (2010)

Miscellaneous

Zaharoni H., Rimon E., Vardi H., Friger M., Bolotin A., Shahar D., Probiotics improve bowel movements in hospitalized elderly patients -The PROAGE study The Journal of Nutrition, Health and Aging (2010) Montalto M., Gallo A., Curigliano V., DOnofrio F., Santoro L., Covino S., Dalvai S., Gasbarrini A. and Gasparrini G. The effects of a probiotic mixture on NSAID enteropathy: a randomized, double-blind, cross-over, placebo-controlled study. Aliment Pharmacol Ther. 32:209-214 (2010)
Okombo J. and Liebman M. Probiotic-induced reduction of gastrointestinal oxalate absorption in healthy subjects. Urol Res 38:169-178 (2010) Brigidi P, Vitali B, Swennen E, Altomare L, Rossi M, Matteuzzi D, Specific Detection of Bifidobacterium Strains in a Pharmaceutical Probiotic Product and in Human Feces by Polymerase Chain Reaction. Syst Appl Microbiol 23:391-399 (2000) Brigidi P, Swennen E,Vitali B, Rossi M, Matteuzzi D. PCR Detection of Bifidobacterium Strains and Streptococcus Thermophilus in Feces of Human Subjects after Oral Bacteriotherapy and Yogurt Consumption. Int J Food Microbiol 81:203-209 (2003)

In vivo studies

Hrmannsperger G, Clavel T, Hoffmann M, Reiff C, Kelly D, Loh G, Blaut M, Hlzlwimmer G, Haller D. Posttranslational Inhibition of Proinflammatory Chemokine Secretion in Intestinal Epithelial Cells: Implications for Specific IBD Indications. J Clin Gastroenterol. 44 :S10-5. (2010) Reiff, C., Delday M., Rucklidge G., Reid M., Duncan G., Wohlgemuth S. ,Hormannsperger G., Loh G., Blaut M. Collie-Duguid E., Haller D.and Kelly D. Balancing Inflammatory, Lipid, and Xenobiotic Signaling Pathways by VSL#3, a Biotherapeutic Agent, in the Treatment of Inflammatory Bowel Disease Inflamm Bowel Dis 11:1721-36 (2009) Arslan H.H., Gulbahar M.Y., Yavuz O., Bozkurt A., Terzi G. Effect of Different Probiotics in Indomethacin-Induced Inflammatory bowel disease in Rats. Dtsch Tierrztl Wochenschr 116, 1118 2009

Liver Diseases:

Esposito E., Iacono A., Bianco G., Autore G., Cuzzocrea S., Vajro P., Canini RB., Calignano A., Raso GM., Meli R. Probiotics reduce the inflammatory response induced by a High-Fat Diet in the liver of young rats. J. Nutrition and Disease.139:1-7 (2009). Velayudham A, Dolganiuc A, Ellis M, Petrasek J, Kodys K, Mandrekar P, Szabo G. VSL#3 Probiotic Treatment Attenuates Fibrosis Without Changes in Steatohepatitis in a Diet-Induced Nonalcoholic Steatohepatitis Model in Mice. Hepatology 49: 989-Ma X, Hua J, Li Z Probiotics improve high fat diet-induced hepatic steatosis and insulin resistance by increasing hepatic NKT cells Journal of Hepatology 49:821-30 (2008) Ewaschuk J, Endersby R, Thiel D, Diaz H, Backer J, Mang M, Churchill T, Madsen K Probiotic bacteria prevent hepatic damage and maintain colonic barrier function in a mouse model of sepsis Hepatology 46:841-850 (2007)

Diabetes:

Calcinaro F, Dionisi S, Marinaro M, Candeloro P, Bonato V, Marzotti S, Corneli RB, Ferretti E, Gulino A, Grasso F, De Simone C, Di Mario U, Falorni A, Boirivant M, Dotta F. Oral probiotic administration induces interleukin-10 production and prevents spontaneous autoimmune diabetes in the non-obese diabetic mouse. Diabetologia 48:1565-75 (2005)

Immuno-disease

Schiavi E., Barletta B., Butteroni C., Corinti S., Boirivant M. e Di Felice G., Oral therapeutic administration of a probiotic mixture suppresses established Th2 responses and systemic anaphylaxis in a murine model of food allergy Allergy 66: 499508 (2011). Pagnini C, Saeed R, Bamias G, Arseneau KO, Pizarro TT, Cominelli F. Probiotics promote gut health through stimulation of epithelial innate immunity. PNAS 107:454-459 (2010) Wang X., OGorman M. R. G., Bu H.F., Koti V., Zuo X.-Li, and Tan X-D. Probiotic Preparation VSL#3 Alters the Distribution and Phenotypes of Dendritic Cells within the Intestinal Mucosa in C57BL/10J Mice. Journal of Nutrition 139:1-8 (2009) Mastrangeli G, Corinti S, Butteroni C, Afferni C, Bonura A, Boirivant M, Colombo P, Di Felice G. Effects of live and inactivated VSL#3 probiotic preparations in the modulation of in vitro and in vivo allergen-induced Th2 responses Arch of Int Allergy and Immunology 150:133143 ( 2009) Jijon H, Backer J, Diaz H, Yeung H, Thiel D, Mc Kaigney C, De Simone C, Madsen K. DNA from probiotic bacteria modulates murine and human epithelial and immune function. Gastroenterology 126:1358-73 (2004)

Uronis JM, Arthur JC, Keku T, Fodor A, Carroll IM, Cruz ML, Appleyard CB, Jobin C. Gut microbial diversity is reduced by the probiotic VSL#3 and correlates with decreased TNBS-induced colitis. Inflamm Bowel Dis. 17:289-97 (2011) Hrmannsperger G, Clavel T, Hoffmann M, Reiff C, Kelly D, Loh G, Blaut M, Hlzlwimmer G, Laschinger M , Haller D. Post-translational Inhibition of IP-10 Secretion in IEC by Probiotic Bacteria: Impact on Chronic Inflammation Secretional Blockade by VSL#3 Plos One 4:e4365 (2009) Mennigen R, Nolte K, Rijcken E, Utech M, Loeffler B, Senninger N, Bruewer M. Probiotic mixture VSL#3 protects the epithelial barrier by maintaining tight junction protein expression and preventing apoptosis in a murine model of colitis. Am J Physiol Gastrointest Liver Physiol 296:G1140-G1149 (2009).
Harding S.V., Fraser K.G., Wykes L.J. Probiotics stimulate liver and plasma protein synthesis in piglets with dextran Sulfate-Induced Colitis and macronutrient restriction. The Journal of Nutrition 138:2129-2135 (2008). Kotka M., Lieden A., Petterson S., Trinchieri V., Masci A., DAmato M. Solute Carriers (SLC) in inflammatory Bowel Disease. A potential target of probiotics? J Clin Gastroenterol Vol 42 Supp.3 (2008) Soo I, Madsen KL, Qassim T, Sydora BC, Sherbaniuk R, Cinque B, Di Marzio L, Cifone MG, De Simone C, Fedorak RN VSL#3 probiotic upregulates intestinal mucosal alkaline sphingomyelinase and reduces inflammation Can J Gastroenterol 22:237-242 (2008) Fitzpatrick LR, Hertzog KL, Quatse AL, Koltun WA, Small JS, Vrana K Effects of the probiotic formulation VSL#3 on colitis in weanling rats J Pediatric Gastroenterology and Nutrition 44:561570 (2007) Caballero-Franco C, Keller K, De Simone C, Chadee K The VSL#3 probiotic formula induces mucin gene expression and secretion in colonic epithelial cells Am J Physiol Gastrointest Liver Physiol 292:G315-22 (2007) Ewaschuk JB, Walker JW, Diaz H, Madsen KL. Bioproduction of conjugated linoleic Acid by probiotic bacteria occurs in vitro and in vivo in mice. J Nutr 136(6):1483-7 (2006) Gaudier E, Michel C, Segain JP, Cherbut C, Hoebler C. The VSL#3 probiotic mixture modifies microflora but does not heal chronic dextran-sodium sulfate-induced colitis or reinforce the mucus barrier in mice J Nutr 135:2753-61 (2005) Linsalata M, Russo F, Berloco P, Valentini AM, Caruso ML, De Simone C, Barone M, Polimeno L, Di Leo A. Effects of probiotic bacteria (VSL#3) on the poliamine biosynthesis and cell proliferation of normal colonic mucosa of rats In Vivo 19:989-996 (2005) Di Giacinto C, Marinaro M, Sanchez M, Strober W, Boirivant M. Probiotics Ameliorate Recurrent Th1-Mediated Murine Colitis by Inducing IL-10 and IL-10-Dependent TGF--Bearing Regulatory Cells. J Immunol 174:3237-46 (2005) Rachmilewitz D, Katakura K, Karmeli F, Hayashi T, Reinus C, Rudensky B, Akira S, Takeda K, Lee J, Takabayashi K, Raz E. Toll-Like Receptor 9 Signaling Mediates the Anti-inflammatory Effects of Probiotics in Murine Experimental Colitis. Gastroenterology 126 : 520-528 (2004) Shibolet O, Karmeli F, Eliakim R, Swennen E, Brigidi P, Gionchetti P, Campieri M, Morgenstern S, Rachmilewitz D. Variable Response to Probiotics in Two Models of Experimental Colitis in Rats. Inflamm Bowel Dis 8:399-406 (2002) Madsen K, Cornish A, Soper P, Mc Kaigney C, Jijon H, Yachimec C, Doyle J, Jewell L, De Simone C, Probiotic Bacteria Enhance Murine and Human Intestinal Epithelial Barrier Function. Gastroenterology 121:580-591 (2001)

In vitro studies

Ulcerative colitis:
Visekruna A, Joeris T, Seidel D, Kroesen A, Loddenkemper C, Zeitz M, Kaufmann SHE, SchmidtUllrich R, Steinhoff U Proteasome-mediated degradation of IB and processing of p105 in Crohns disease and ulcerative colitis J Clin Invest 116:3195-203. (2006)
Li Z, Yang S, Lin H, Huang J, Watkins PA, Moser AB, De Simone C, Song X, Diehl AM. Probiotics and Antibodies to TNF Inhibit Inflammatory Activity and Improve Non-Alcoholic Fatty Liver Disease. Hepatology 37:343-350 (2003)
Schiavi E., Barletta B., Butteroni C., Corinti S., Boirivant M. e Di Felice G., Oral therapeutic administration of a probiotic mixture suppresses established Th2 responses and systemic anaphylaxis in a murine model of food allergy Allergy 66: 499508 (2011). Pagnini C, Saeed R, Bamias G, Arseneau KO, Pizarro TT, Cominelli F. Probiotics promote gut health through stimulation of epithelial innate immunity. PNAS 107:454-459 (2010) Mastrangeli G, Corinti S, Butteroni C, Afferni C, Bonura A, Boirivant M, Colombo P, Di Felice G. Effects of live and inactivated VSL#3 probiotic preparations in the modulation of in vitro and in vivo allergen-induced Th2 responses Arch of Int Allergy and Immunology 150:133143 ( 2009) Hart AL, Lammers K, Brigidi P,Vitali B, Rizzello F, Gionchetti P, Campieri M, Kamm MA, Knight SC, Stagg AJ. Modulation of human dendritic cell phenotype and function by probiotic bacteria. Gut 53:1602-1609 (2004) Drakes M, Blanchard T, Czinn S. Bacterial probiotic modulation of dendritic cells. Infect Immun 72:3299-309 (2004) Lammers KM, Brigidi P, Vitali B, Gionchetti P, Rizzello F, Caramelli E, Matteuzzi D, Campieri M. Immunomodulatory effects of probiotic bacteria DNA: IL-1 and IL-10 response in human peripheral blood mononuclear cells. FEMS Immunol Med Microbiol 38:165-72 (2003)
Otte JM, Rudja MN, Brand S, Ilka W, Wolfgang E. Schmidt, Schmitz F. Probiotics Regulate the Expression of COX-2 in Intestinal Epithelial Cells Nutrition and Cancer 61: 103-113 (2009) Schlee M, Harder J, Kten B, Stange EF, Wehkamp J, Fellermann K Probiotic lactobacilli and VSL#3 induce enterocyte -defensin 2 Clin Experim Immunol 151:528-35 (2008)
De Angelis M, Rizzello CG, Scala E, De Simone C, Farris GA, Turrini F, Gobbetti M preparation has the capacity to hydrolyze proteins responsible for wheat allergy 70:135-144 (2007)

Probiotic J Food Prot

Massi M, Ioan P, Budriesi R, Chiarini C, Vitali B, Lammers KM, Gionchetti P, Campieri M, Lembo A, Brigidi P Effects of probiotic bacteria on gastrointestinal motility in Guinea-pig isolated tissue World J Gastroenterol 12:5987-94 (2006) Helwig U, Lammers KM, Rizzello F, Brigidi P, Rohleder V, Caramelli E, Gionchetti P, Schrezenmeir J, Foelsch UR, Schreiber S, Campieri M Lactobacilli, bifidobacteria and E. coli nissle induce proand anti-inflammatory cytokines in peripheral blood mononuclear cells World J Gastroenterol 12:5978-86 (2006) De Angelis M, Rizzello CG, Fasano A, Clemente MG, De Simone C, Silano M, De Vincenzi M, Losito I, Gobbetti M. VSL#3 probiotic preparation has the capacity to hydrolyze gliadin polypeptides responsible for celiac sprue BBA 1762:80-93 (2005) Petrof EO, Kojima K, Ropeleski MJ, Musch MW, Yun Tao, De Simone C, Chang EB. Probiotics inhibit nuclear factor kB and induce heat shock proteins in colonic epithelial cells through Proteasome inhibition. Gastroenterology 127:1474-1487 (2004) Otte JM, Podolsky DK. Functional modulation of enterocytes by gram-positive and gram-negative microorganisms. Am J Physiol Gastrointest Liver Physiol 286: G613G626 (2004) Vitali B., Candela M., Matteuzzi D., Brigidi P., Quantitative detection of probiotic Bifidobacterium strains in bacterial mixtures by using real-time PCR. Syst Appl Microbiol 26:269-76 (2003) Lammers KM, Helwig U, Swennen E, Rizzello F, Venturi A, Caramelli E, Kamm M, Brigidi P, Gionchetti P, Campieri M. Effect of Probiotic Strains on Interleukin 8 Production by HT29/19A Cells. Am J Gastroenterology 97:1182-1186 (2002)