http://www.Alfred.TV READ ME FIRST: In this video, we document the amazing kludge job that was beautifully executed by AdamB ...
NEW!! NeuronVS is back: http://www.neuronsynth.com Introduction of the Hartmann Neuron synthesizer by Axel Hartmann.
NEW!! NeuronVS is back: http://www.neuronsynth.com Hans Zimmer talks about the Hartmann Neuron synthesizer. Courtesy of ...
J Musculoskel Neuron Interact 2002; 2(3):274-276
Wnt-signaling and skeletogenesis
Department of Genetics, Harvard Medical School, Boston, MA, USA
Abstract Members of the Wnt gene family, encoding secreted cystein-rich glycoproteins, have been isolated from a variety of organisms. They serve as important developmental signaling molecules and have been implicated to play crucial roles in such diverse processes as cancer, organogenesis and pattern formation. Experiments by Zakany and Duboule10, and Rudnicki and Brown11 have suggested a role for Wnt molecules in negatively regulating chondrogenesis. However, neither of the two Wnt genes used in these studies is endogenously expressed in chondrogenic regions. We and others have found that in the chick limb at least four members of the Wnt gene family, Wnt-4, Wnt-5a, Wnt-5b, and Wnt-14, are expressed in defined regions of the developing chondrogenic elements. With the exception of Wnt-5b, which is expressed in ...